Recent Advances in Alkyne Hydroamination as a Powerful Tool for the Construction of C−N Bonds,Asian Journal of Organic Chemistry

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Recent Advances in Alkyne Hydroamination as a Powerful Tool for the Construction of C−N Bonds
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-04-23 , DOI: 10.1002/ajoc.202000092
Zahra Tashrifi ₁ , Mohammad Mohammadi Khanaposhtani ₂ , Mahmood Biglar ₁ , Bagher Larijani ₁ , Mohammad Mahdavi ₁

Affiliation

Alkyne hydroamination reaction has attracted many researchers due to its capability to form the required C−N bonds in the synthesis of the biologically and pharmacologically active N‐heterocycles. Hence, in this review, a comprehensive and updated summary of the research progress in this area (from 2014 on) is presented. In order to provide an easier access to the required information, a brief and concise description of the reaction mechanisms and preparation of precursors is also included, where possible. Accordingly, the alkyne hydroamination reactions are classified and summarized based on the type of hydroamination (inter‐ or intramolecular) and each class is further subdivided according to the number of members in the rings, so as to help the researchers in designing new N‐hetrocycles.

中文翻译：

炔烃加氢胺化作为构建CN键的有力工具的最新进展

炔烃加氢胺化反应由于能够在生物和药理活性N杂环的合成中形成所需的C-N键而吸引了许多研究人员。因此，在这篇综述中，提供了该领域研究进展的全面，更新的摘要（自2014年起）。为了提供对所需信息的更容易访问，在可能的情况下，还包括对反应机理和前体制备的简要说明。因此，根据氢化胺的类型（分子间或分子内）对炔烃的氢化胺化反应进行分类和归纳，并根据环中的成员数进一步细分每一类，以帮助研究人员设计新的N摩托车。

更新日期：2020-04-23

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