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A reactive metabolite as an immune suppressant.
Nature Immunology ( IF 27.7 ) Pub Date : 2020-05-01 , DOI: 10.1038/s41590-020-0664-y
Vijyendra Ramesh 1 , Jason W Locasale 1
Affiliation  

Myeloid-derived suppressor cells (MDSCs) occupy sites of chronic inflammation and suppress CD8+ T cell function. A new study describes the transfer of the metabolite methylglyoxal (MG) to T cells, which mediates this immunosuppressive mechanism.

中文翻译:

反应性代谢产物作为免疫抑制剂。

骨髓来源的抑制细胞(MDSCs)占据了慢性炎症的位置,并抑制CD8 + T细胞的功能。一项新的研究描述了代谢物甲基乙二醛(MG)向T细胞的转移,它介导了这种免疫抑制机制。
更新日期:2020-04-24
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