How does the folding of the genome relate to the regulation of gene expression? Using fly embryos and quantitative live imaging, a recent study by Yokoshi et al. reveals that the answer might depend on whether enhancer–promoter communication occurs inside or in-between topological domains.

中文翻译：

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促进者与促进者的沟通：在TAD之外进行思考。

基因组的折叠与基因表达的调控有何关系？Yokoshi等人最近的一项研究使用果蝇胚胎和定量实时成像技术。揭示出答案可能取决于增强子与启动子的通信是在拓扑域内部还是在拓扑域之间发生。