Objective

Metabolic bone disease concerns a broad spectrum of conditions related to reduced bone density. Metabolic bone disease has been linked to chronic inflammatory diseases, such as ulcerative colitis. This study examines the prevalence of metabolic bone disease in ulcerative colitis patients and explores possible clinical predictors.

Method

The authors performed a retrospective study involving children and adolescents with confirmed ulcerative colitis between January 2013 and December 2018. Bone density was evaluated through a dual-energy X-ray absorptiometry scan of the spine and total body. Osteoporosis was defined as a bone mineral density Z-score of <−2 and osteopenia as a Z-score of between −1.0 and −2.

Results

A total of 37 patients were included in this analysis, with a mean age of 13.4 ± 3.9 years and a mean duration of illness of 2.1 ± 2.4 years. Using lumbar spine Z-scores and total body Z-scores, osteoporosis and osteopenia were identified by dual-energy X-ray absorptiometry scan measurements in 11 patients (29.7%) and 15 patients (40.5%), and in ten patients (27%) and 13 patients (35%), respectively. Lumbar spine Z-scores were significantly positively associated with male gender (B = 2.02; p = 0.0001), and negatively associated with the presence of extraintestinal manifestations (B = −1.51, p = 0.009) and the use of biologics (B = −1.33, p = 0.004). However, total body Z-scores were positively associated with body mass index Z-scores (B = 0.26, p = 0.004) and duration of illness in years (B = 0.35, p = 0.003).

Conclusions

Metabolic bone disease is very common in this cohort of Saudi Arabian children and adolescents with ulcerative colitis and its occurrence appears to increase in female patients who suffer from extraintestinal manifestations.

中文翻译：

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儿童和青少年溃疡性结肠炎患者的代谢性骨病

客观的

代谢性骨病涉及与骨密度降低相关的广泛疾病。代谢性骨病与溃疡性结肠炎等慢性炎症性疾病有关。本研究检查了溃疡性结肠炎患者中代谢性骨病的患病率，并探索了可能的临床预测因素。

方法

作者对 2013 年 1 月至 2018 年 12 月期间确诊为溃疡性结肠炎的儿童和青少年进行了一项回顾性研究。通过脊柱和全身的双能 X 射线骨密度仪扫描评估骨密度。骨质疏松症定义为骨矿物质密度Z值 <-2，骨质减少定义为Z值介于 -1.0 和 -2 之间。

结果

该分析共纳入 37 名患者，平均年龄为 13.4  ±  3.9 岁，平均病程为 2.1  ±  2.4 年。使用腰椎Z评分和全身Z评分，通过双能 X 射线骨密度仪扫描测量，11 名患者 (29.7%) 和 15 名患者 (40.5%) 和 10 名患者 (27%) 确定了骨质疏松症和骨质减少) 和 13 名患者 (35%)。腰椎Z值与男性呈显着正相关（B  =  2.02；p  =  0.0001），与肠外表现呈负相关（B  =  -1.51，p  = 0.009）和生物制剂的使用（B  =  -1.33，p  =  0.004）。然而，全身Z分数与体重指数Z分数（B  =  0.26，p  =  0.004）和病程年数（B  =  0.35，p  =  0.003）呈正相关。

结论

代谢性骨病在这群患有溃疡性结肠炎的沙特阿拉伯儿童和青少年中非常常见，并且在患有肠外表现的女性患者中其发生率似乎有所增加。