Faithful establishment and maintenance of proportion is seen across biological systems and provides a glimpse at fundamental rules of scaling that underlie development and evolution. Dysregulation of proportion is observed in a range of human diseases and growth disorders, indicating that proper scaling is an essential component of normal anatomy and physiology. However, when viewed through an evolutionary lens, shifts in the regulation of relative proportion are one of the most striking sources of morphological diversity among organisms. To date, the mechanisms via which relative proportion is specified and maintained remain unclear. Through the application of powerful experimental, genetic and molecular approaches, the teleost fin has provided an effective model to investigate the regulation of scaling, size, and relative growth in vertebrate organisms.

中文翻译：

---

透过隐蔽的镜子：鱼鳍洞察尺寸调节

在整个生物系统中都可以看到忠实地建立和维持比例，并提供了对发展和进化基础的缩放基本规则的一瞥。在一系列人类疾病和生长障碍中观察到比例失调，表明适当的缩放是正常解剖学和生理学的重要组成部分。然而，从进化的角度来看，相对比例调节的变化是生物体形态多样性最显着的来源之一。迄今为止，相对比例被指定和维持的机制仍不清楚。通过应用强大的实验、遗传和分子方法，硬骨鱼鳍提供了一个有效的模型来研究尺度、大小、