Pre-pubertal, low-intensity exercise does not require concomitant venlafaxine to induce robust, late-life antidepressant effects in Flinders sensitive line rats.,European Journal of Neuroscience

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Pre-pubertal, low-intensity exercise does not require concomitant venlafaxine to induce robust, late-life antidepressant effects in Flinders sensitive line rats.
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-04-22 , DOI: 10.1111/ejn.14757
Stephan F Steyn ₁ , Brian H Harvey ₁ , Christiaan B Brink ₁

Affiliation

A significant number of adolescents are considered insufficiently active. This is of concern considering the negative association between physical activity and major depressive disorder (MDD). There is a lack of approved pharmacological treatment options in this population partly due to limited information on the risks associated with lasting effects during early life. Therefore, interest in non‐pharmacological strategies is gaining popularity with low‐ to moderate‐intensity exercise being especially attractive for its antidepressant‐like effects and augmentation properties in combination with antidepressants. Early‐life development might present a unique “window of opportunity” to induce long‐term beneficial effects in individuals treated with central acting drugs, such as antidepressants. Therefore, we investigated the bio‐behavioural effects of pre‐pubertal, low‐intensity exercise (EXE) and/or venlafaxine (VEN) on depressive‐like behaviour in juvenile (postnatal day 35 (PND35)) and young adult (PND60) stress‐sensitive Flinders sensitive line (FSL) rats. Interventions were introduced during pre‐pubertal development, that is PND21‐34, followed by a 26‐day washout/sedentary period, when bio‐behavioural analyses were performed in the early adulthood group. VEN, alone or in combination with EXE, proved ineffective in inducing any bio‐behavioural changes in either age group. EXE did not induce early‐life antidepressant‐like effects, despite increasing frontal serotonin (5‐HT) and noradrenaline (NA) levels. Later in life (PND60), pre‐pubertal exercise reduced immobility and increased coping behaviours, together with increased cortical 5‐HT levels, despite a significant reduction in locomotor activity. These findings emphasize a strong serotonergic basis to the observed delayed antidepressant effects of EXE later in life.

中文翻译：

青春期前的低强度运动不需要伴随的文拉法辛在Flinders敏感品系大鼠中诱导强大的抗衰老作用。

相当多的青少年被认为活动不足。考虑到体育锻炼与重度抑郁症（MDD）之间的负相关性，这是令人关注的问题。该人群中缺乏经过批准的药物治疗选择，部分原因是有关与生命早期持久影响相关的风险的信息有限。因此，对非药物治疗策略的兴趣日益浓厚，中低强度的运动因其抗抑郁样作用和与抗抑郁药相结合的增强特性而特别具有吸引力。早期发展可能会提供独特的“机会之窗”，以在接受抗抑郁药等中枢性药物治疗的个体中引起长期的有益影响。因此，我们调查了青春期前（低出生后35天（PND35））和年轻人（PND60）对压力敏感的青春期前低强度运动（EXE）和/或文拉法辛（VEN）对抑郁样行为的生物行为影响弗林德斯敏感系（FSL）大鼠。在青春期前阶段即PND21-34期间进行干预，然后在成年早期组进行生物行为分析，然后进行26天的冲洗/静息期。VEN单独使用或与EXE联合使用均被证明对引起任何年龄段的任何生物行为变化均无效。尽管额叶血清素（5-HT）和去甲肾上腺素（NA）含量增加，但EXE并没有诱发早期抗抑郁样作用。在生命的后期（PND60），青春期前的运动减少了不动，增加了应对行为，同时皮质5-HT水平升高，尽管运动活动明显减少。这些发现强调了在生命后期观察到的EXE延迟抗抑郁作用的强大的血清素能基础。

更新日期：2020-04-22

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