Behavioral components of chromosome 22q11.2 deletion syndrome (22q), caused by the most common human microdeletion, include cognitive and adaptive functioning impairments, heightened anxiety, and an elevated risk of schizophrenia. We investigated how interactions between executive function and the largely overlooked factor of emotion regulation might relate to the incidence of symptoms of psychotic thinking in youth with 22q. We measured neural activity with event‐related potentials (ERPs) in variants of an inhibitory function (Go/No‐Go) experimental paradigm that presented affective or non‐affective stimuli. The study replicated inhibition impairments in the 22q group that were amplified in the presence of stimuli with negative, more than positive affective salience. Importantly, the anterior N2 conflict monitoring ERP significantly increased when youth with 22q viewed angry and happy facial expressions, unlike the typically developing participants. This suggests that youth with 22q may require greater conflict monitoring resources when controlling their behavior in response to highly salient social signals. This evidence of both behavioral and neurophysiological differences in affectively influenced inhibitory function suggests that frequently anxious youth with 22q may struggle more with cognitive control in emotionally charged social settings, which could influence their risk of developing symptoms of psychosis.

中文翻译：

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神经和行为测量表明，认知和情感功能的相互作用介导了患有 22q11.2 染色体缺失综合征的青年精神病倾向症状的风险。

由最常见的人类微缺失引起的染色体 22q11.2 缺失综合征 (22q) 的行为成分包括认知和适应功能障碍、焦虑加剧和精神分裂症风险升高。我们调查了执行功能和很大程度上被忽视的情绪调节因素之间的相互作用如何与 22q 青年精神病性思维症状的发生率相关。我们在呈现情感或非情感刺激的抑制功能 (Go/No-Go) 实验范式的变体中测量了具有事件相关电位 (ERP) 的神经活动。该研究复制了 22q 组中的抑制损伤，这些损伤在存在具有负面而非正面情感显着性的刺激时被放大。重要的，与正常发育的参与者不同，当 22q 的年轻人看到愤怒和快乐的面部表情时，前 N2 冲突监测 ERP 显着增加。这表明具有 22q 的青年在控制他们的行为以响应高度显着的社会信号时可能需要更多的冲突监测资源。情感影响抑制功能的行为和神经生理学差异的证据表明，经常焦虑的 22q 青年可能在情绪激动的社会环境中更难以控制认知，这可能会影响他们出现精神病症状的风险。这表明具有 22q 的青年在控制他们的行为以响应高度显着的社会信号时可能需要更多的冲突监测资源。情感影响抑制功能的行为和神经生理学差异的证据表明，经常焦虑的 22q 青年可能在情绪激动的社会环境中更难以控制认知，这可能会影响他们出现精神病症状的风险。这表明具有 22q 的青年在控制他们的行为以响应高度显着的社会信号时可能需要更多的冲突监测资源。情感影响抑制功能的行为和神经生理学差异的证据表明，经常焦虑的 22q 青年可能在情绪激动的社会环境中更难以控制认知，这可能会影响他们出现精神病症状的风险。