Introduction: Diagnostic and therapeutic strategies in eosinophilic esophagitis (EoE) are constantly evolving. Recently, the improved understanding of EoE pathogenesis has led to identification of a variety of other potential targets that have never been considered before.Areas covered: In September 2019, we performed structured literature searches in Medline and PubMed, Cochrane meta-analyses, and abstracts of international congresses to review new potential therapeutic approaches for EoE.Expert opinion: The advent of omics disciplines has been helping in finding new molecular targets in EoE pathogenesis and may provide future guidance for deep phenotyping of the disease and therefore facilitate the possibility of personalized medicine. Interestingly, these new treatments should be focused on the restoration of epithelial barrier dysfunction, downregulation of specific molecular pathways of eosinophilic inflammation, and finally, prevention of esophageal remodeling. In this review, we highlight the most recent insights in EoE pathogenesis, which open new pathways for developing new therapeutic targets for clinical practice.

中文翻译：

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嗜酸性粒细胞性食管炎治疗潜在靶点的最新进展。

简介：嗜酸性粒细胞性食管炎 (EoE) 的诊断和治疗策略在不断发展。最近，对 EoE 发病机制的深入理解导致发现了许多以前从未考虑过的其他潜在目标。 涵盖的领域：2019 年 9 月，我们在 Medline 和 PubMed、Cochrane 荟萃分析和摘要中进行了结构化文献搜索国际大会审查 EoE 新的潜在治疗方法。 专家意见：组学学科的出现一直在帮助寻找 EoE 发病机制中的新分子靶点，并可能为疾病的深层表型分析提供未来指导，从而促进个性化医疗的可能性. 有趣的是，这些新疗法应该侧重于上皮屏障功能障碍的恢复，嗜酸性炎症的特定分子通路的下调，最后，预防食管重塑。在这篇综述中，我们重点介绍了 EoE 发病机制的最新见解，这为开发新的临床实践治疗靶点开辟了新途径。