Symmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.

中文翻译：

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环酮的某些合成双（芳基）衍生物对顺铂耐药的人卵巢癌细胞的细胞毒性

通过在脂肪族酮（例如环戊酮，4-烷基环己酮，四氢吡喃-4-酮和四氢噻喃-4-酮）和两个当量的芳族羟基醛之间进行酸催化的醛醇缩合反应，可制得对称的α，αʹ-双（亚芳基）酮。 （例如4-羟基苯甲醛，3,4-二羟基苯甲醛，香兰素，异香兰素和3-氟-4-羟基苯甲醛）。大多数化合物对顺铂耐药的人类卵巢癌细胞系A2780-CP70和非耐药的A2780细胞具有细胞毒性。