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Three new quassinoids isolated from the wood of Picrasma javanica and their anti-Vpr activities.
Journal of Natural Medicines ( IF 2.055 ) Pub Date : 2020-04-23 , DOI: 10.1007/s11418-020-01411-y
Prema,Chin Piow Wong,Takeshi Kodama,Alfarius Eko Nugroho,Ahmad H El-Desoky,Maurice Ducret Awouafack,Yi Yi Win,Hla Ngwe,Ikuro Abe,Hiroshi Morita,Hiroyuki Morita

Three new quassinoids, javanicinols A and B (1 and 2) and 4-keto-(16S)-methoxyjavanicin B (3), together with three known quassinoids (4-6) were isolated from the chloroform-soluble fraction of the methanol extract of the Picrasma javanica wood. The structures of 1-3 were determined by spectroscopic analyses, including 1D and 2D NMR, HRESIMS, and CD. The anti-HIV-1 viral protein R (Vpr) assay revealed that 1 and 2 exhibited potent anti-Vpr activities at 1.25 μM. Furthermore, the assay also revealed the potent anti-Vpr activities of (16R)-methoxyjavanicin B (7) and (16S)-methoxyjavanicin B (8), which were previously isolated from the Picrasma javanica wood.
更新日期:2020-04-23

 

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