Three new quassinoids, javanicinols A and B (1 and 2) and 4-keto-(16S)-methoxyjavanicin B (3), together with three known quassinoids (4–6) were isolated from the chloroform-soluble fraction of the methanol extract of the Picrasma javanica wood. The structures of 1–3 were determined by spectroscopic analyses, including 1D and 2D NMR, HRESIMS, and CD. The anti-HIV-1 viral protein R (Vpr) assay revealed that 1 and 2 exhibited potent anti-Vpr activities at 1.25 μM. Furthermore, the assay also revealed the potent anti-Vpr activities of (16R)-methoxyjavanicin B (7) and (16S)-methoxyjavanicin B (8), which were previously isolated from the Picrasma javanica wood.

中文翻译：

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从爪哇Picrasma木材中分离出的三种新类quassinoids及其抗Vpr活性。

从甲醇的可溶于氯仿的馏分中分离出三个新的类胡萝卜素，javanicinols A和B（1和2）和4-酮-（16 S）-甲氧基javanicin B（3），以及三个已知的类quassinoids（4–6）。Picrasma javanica木头的提取物。1-3的结构通过光谱分析确定，包括1D和2D NMR，HRESIMS和CD。抗HIV-1病毒蛋白R（Vpr）分析显示1和2在1.25μM时显示出强大的抗Vpr活性。此外，该测定还显示了（16 R）-甲氧基javanicin B的强抗Vpr活性（7）和（16 S）-甲氧基javanicin B（8），它们先前是从印度苦木中分离出来的。