Contact dermatitis linked to cosmetic products is a very common reason for visits to the dermatologist, and in more than half the cases, it is due to an allergic reaction. Fragrances are most often the culprit. The aim of the study was to describe the common fragrance allergens in different categories of cosmetic products available on the European market. We wanted to assess the influence of cosmetic type and distribution channel on the presence of fragrance allergens. There are the allergens whose concentration exceeds 0.001% in leave-on products and 0.01% in rinse-off products. A total of 2044 commercial hygiene, care, and makeup cosmetic products were analyzed to specifically study regulated fragrance allergens. The influence that the product category and its distribution channel (retail stores and specialized stores such as beauty institutes or hairdressers and pharmacy) have on the prevalence of these allergens was evaluated. The Kruskal-Wallis test has been used for statistical data analysis. There is a wide range of fragrance allergens, the most common being limonene (found in about 30% of products tested), linalool (just over a quarter of the products tested), and benzyl alcohol (approximately 16% of the products tested). The average number of allergens found and their nature varies depending on the type of product in question (maximum number for shampoos and oral care with about 70 allergens and minimum number for nail polish and makeup for eyes with fewer than 10 allergens). In the area of hygiene, deodorants and oral hygiene products are particularly noteworthy, the former for their significantly high number of allergens and the latter for their low number. There is also a significant difference between the number of allergens found in eye makeup and foundations. Our results indicate that the number of regulated fragrance allergens is particularly influenced by the type of products.

中文翻译：

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化妆品类型和分销渠道对受管制的香料过敏原的影响：2044商业产品的研究。

与化妆品相关的接触性皮炎是拜访皮肤科医生的非常普遍的原因，在一半以上的情况下，这是由于过敏反应引起的。香水通常是罪魁祸首。该研究的目的是描述欧洲市场上各种化妆品中常见的香料过敏原。我们想评估化妆品类型和分销渠道对香料过敏原存在的影响。有些过敏原在免洗产品中的浓度超过0.001％，在漂洗产品中的浓度超过0.01％。总共对2044种商业卫生，护理和化妆品化妆品进行了分析，以专门研究受管制的香料过敏原。评估了产品类别及其分销渠道（零售商店和专门商店，例如美容院或美发店和药房）对这些过敏原的患病率的影响。Kruskal-Wallis检验已用于统计数据分析。香精过敏原种类繁多，最常见的是柠檬烯（在约30％的被测产品中发现），芳樟醇（仅占被测产品的四分之一以上）和苯甲醇（约占被测产品的16％）。发现的平均过敏原数量及其性质取决于所讨论产品的类型（洗发水和口腔护理的最大数量（约70种过敏原）和指甲油和化妆品的最小数量（少于10种过敏原的眼睛））。在卫生方面，除臭剂和口腔卫生产品尤其值得一提，前者的过敏原数量很高，而后者的数量很少。眼部化妆品和粉底中发现的过敏原数量也存在显着差异。我们的结果表明，受规管的香料过敏原的数量特别受产品类型的影响。