当前位置：
X-MOL 学术
›
Nanomed. Nanotech. Biol. Med.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Reperfusion combined with intraarterial administration of resveratrol-loaded nanoparticles improved cerebral ischemia-reperfusion injury in rats.
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 4.2 ) Pub Date : 2020-04-23 , DOI: 10.1016/j.nano.2020.102208 Xiaowei Lu 1 , Jingde Dong 2 , Donghui Zheng 3 , Xiaolin Li 1 , Dan Ding 4 , Huae Xu 5
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 4.2 ) Pub Date : 2020-04-23 , DOI: 10.1016/j.nano.2020.102208 Xiaowei Lu 1 , Jingde Dong 2 , Donghui Zheng 3 , Xiaolin Li 1 , Dan Ding 4 , Huae Xu 5
Affiliation
|
Endovascular thrombectomy (EVT) has been recommended as the first line therapy for large artery occlusion (LAO) stroke. However, abrupt recovery of blood flow induces oxidative stress which breaks down the blood-brain barrier (BBB), activates apoptosis and inhibits neurogenesis. Supplement of exogenous antioxidants to relieve the injuries related to oxidative stress is a rational treatment combined to EVT for acute LAO therapy. Resveratrol (RES), an antioxidant, was encapsulated into polymeric nanoparticles (RES-NPs). In transient middle cerebral artery occlusion (tMCAO) rats, intraarterial administration of RES-NPs demonstrated significant protection against cerebral ischemia/reperfusion (I/R) injuries. RES-NPs attenuated the oxidative stress induced by I/R, prevented brain edema, protected neurons from undergoing apoptosis, and contributed to neurogenesis through enhanced expression of brain-derived neurotrophic factor (BDNF). These results suggested that intra-arterial infusion of RES-NPs in conjunction with EVT could be a potential strategy for the LAO stroke therapy.
中文翻译：
再灌注结合动脉内施用白藜芦醇的纳米颗粒改善了大鼠脑缺血-再灌注损伤。
已建议将血管内血栓切除术（EVT）作为大动脉阻塞（LAO）中风的一线治疗。但是，血流的突然恢复会引起氧化应激，从而破坏血脑屏障（BBB），激活细胞凋亡并抑制神经发生。补充外源性抗氧化剂以减轻与氧化应激有关的伤害是与EVT结合用于急性LAO治疗的合理治疗。白藜芦醇（RES），一种抗氧化剂，被封装到聚合物纳米颗粒（RES-NPs）中。在短暂性脑中动脉阻塞（tMCAO）大鼠中，RES-NPs的动脉内给药显示出对脑缺血/再灌注（I / R）损伤的显着保护作用。RES-NPs减轻了I / R诱导的氧化应激，防止了脑水肿，保护了神经元免于凋亡，并通过增强脑源性神经营养因子（BDNF）的表达来促进神经发生。这些结果表明，动脉内输注RES-NP和EVT可能是LAO中风治疗的潜在策略。
更新日期：2020-04-23
中文翻译：
再灌注结合动脉内施用白藜芦醇的纳米颗粒改善了大鼠脑缺血-再灌注损伤。
已建议将血管内血栓切除术（EVT）作为大动脉阻塞（LAO）中风的一线治疗。但是，血流的突然恢复会引起氧化应激，从而破坏血脑屏障（BBB），激活细胞凋亡并抑制神经发生。补充外源性抗氧化剂以减轻与氧化应激有关的伤害是与EVT结合用于急性LAO治疗的合理治疗。白藜芦醇（RES），一种抗氧化剂，被封装到聚合物纳米颗粒（RES-NPs）中。在短暂性脑中动脉阻塞（tMCAO）大鼠中，RES-NPs的动脉内给药显示出对脑缺血/再灌注（I / R）损伤的显着保护作用。RES-NPs减轻了I / R诱导的氧化应激，防止了脑水肿，保护了神经元免于凋亡，并通过增强脑源性神经营养因子（BDNF）的表达来促进神经发生。这些结果表明，动脉内输注RES-NP和EVT可能是LAO中风治疗的潜在策略。
京公网安备 11010802027423号