C-X-C motif chemokine 17 (CXCL-17) is a novel chemokine that plays a functional role maintaining homeostasis at distinct mucosal barriers, including regulation of myeloid-cell recruitment, angiogenesis, and control of microorganisms. Particularly, CXCL17 is produced along the epithelium of the airways both at steady state and under inflammatory conditions. While increased CXCL17 expression is associated with disease progression in pulmonary fibrosis, asthma, and lung/hepatic cancer, it is thought to play a protective role in pancreatic cancer, autoimmune encephalomyelitis and viral infections. Thus, there is emerging evidence pointing to both a harmful and protective role for CXCL17 in human health and disease, with therapeutic potential for translational applications. In this review, we provide an overview of the discovery, characteristics and functions of CXCL17 emphasizing its clinical potential in respiratory disorders.

CXC 基序趋化因子 17 (CXCL-17) 是一种新型趋化因子，在不同黏膜屏障中发挥维持稳态的功能性作用，包括调节髓细胞募集、血管生成和控制微生物。特别是，CXCL17 是在稳态和炎症条件下沿气道上皮产生的。虽然 CXCL17 表达增加与肺纤维化、哮喘和肺癌/肝癌的疾病进展有关，但它被认为在胰腺癌、自身免疫性脑脊髓炎和病毒感染中发挥保护作用。因此，有新的证据表明 CXCL17 在人类健康和疾病中具有有害和保护作用，具有转化应用的治疗潜力。在这篇综述中，我们概述了这一发现，