Objective

Sleep disorders have a high prevalence among patients with idiopathic pulmonary fibrosis (IPF). The prevalence of restless legs syndrome (RLS) is not known in these patients, neither is its clinical impact as a comorbidity. We investigated the association of RLS with IPF and characterized the clinical features of RLS in a cohort of IPF patients.

Methods

Fifty patients with diagnosis of IPF were prospectively enrolled. RLS was diagnosed using the validated 5-item RLS criteria. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index. The prevalence of RLS in the IPF group was compared to that observed in a group of 293 patients referred for suspect of sleep disorders. The relationships between RLS and clinical parameters were determined using multivariate logistic regression.

Results

Prevalence of RLS in the IPF group was significantly higher than in the control population of patients referred for sleep disorders (IPF: 24%, controls 10%: χ² 6.49, p = 0.011). Higher PSQI score confirmed to be associated with RLS after adjusting for demographics and clinical parameters of disease severity (OR = 1.38, 95%CI 1.08–1.76; p = 0.01).

Conclusions

RLS is highly prevalent in IPF and significantly worsen sleep quality in these patients. The benefit/risk ratio of a specific therapeutic intervention for RLS in IPF should be assessed in further prospective research.

中文翻译：

---

腿不安综合征：特发性肺纤维化的新合并症。

目的

在特发性肺纤维化（IPF）患者中，睡眠障碍患病率很高。这些患者尚不清楚躁动性腿综合征（RLS）的患病率，也没有将其作为合并症的临床影响。我们调查了IPS患者中RLS与IPF的关联，并表征了RLS的临床特征。

方法

前瞻性纳入了50名诊断为IPF的患者。使用经过验证的5个项目的RLS标准诊断RLS。使用匹兹堡睡眠质量指数评估睡眠质量。将IPF组的RLS患病率与293名因怀疑睡眠障碍而转诊的患者进行了比较。RLS和临床参数之间的关系使用多元逻辑回归确定。

结果

在IPF组中的RLS的患病率高的患者的对照群体显著更高称为睡眠障碍（IPF：24％，对照10％：χ ² 6.49，P = 0.011）。调整人口统计学和疾病严重程度的临床参数后，较高的PSQI分数证实与RLS相关（OR = 1.38，95％CI 1.08–1.76； p = 0.01）。

结论

RLS在IPF中高度流行，并且使这些患者的睡眠质量显着恶化。应在进一步的前瞻性研究中评估针对IPF中RLS的特定治疗干预措施的获益/风险比。