Purpose

This retrospective study aims to illustrate the radiographic characteristics of Coronavirus Disease 2019 and the correlation with the clinical course.

Methods

195 hospitalized patients confirmed as Coronavirus Disease 2019 at First Hospital of Changsha, Hunan Province from December 31, 2019 to February 20, 2020 were enrolled. Chest computed tomography scan, clinical data and laboratory tests results were collected accordingly. Variable characteristics were recorded, radiographic evolution and outcome were analyzed along with the time course. Representative laboratory tests results were analyzed based on the image findings.

Results

Majority of the patients showed bilateral (73.8%), multiple lobes involvements (75.9%), peripheral distribution (83.1%), ground-glass opacification (41.0%), increased vascular margins (63.1%), long axis parallelism (55.9%), patchy ground-glass opacities beneath the pleura (51.3%) and consolidation (45.6%). According to the repeated radiology analysis, patients of improving/stable group tended to have younger age compared with worsening group (45.3 ± 15.0 VS. 59.3 ± 13.5, P = 0.001). Based on the laboratory test results, patients with positive image findings shared elder age, 46.0 (35.0–60.0)VS.31.0 (12.0–37.0) P < 0.001, and higher chance developing fever(P < 0.05); higher level of lymphocytes, C-reactive protein, erythrocyte sedimentation rate and lactate dehydrogenase; lower level of white blood cells, neutrophil and albumin(P < 0.001).

Conclusions

There are several specific image changes along with the disease progression may be helpful in early recognition and differential diagnosis of Coronavirus Disease 2019. Comprehensive assessments of both imaging feature and laboratory test results may offer an intact knowledge of Coronavirus Disease 2019.

中文翻译：

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胸部 CT 特征与 2019 年冠状病毒病临床病程的关联。

目的

这项回顾性研究旨在说明 2019 年冠状病毒病的放射学特征以及与临床病程的相关性。

方法

入组2019年12月31日至2020年2月20日在湖南省长沙市第一医院确诊为2019冠状病毒病的住院患者195例。相应地收集胸部计算机断层扫描、临床数据和实验室检查结果。记录变量特征，分析放射学演变和结果以及时间进程。基于图像发现分析了有代表性的实验室测试结果。

结果

大多数患者表现为双侧（73.8%）、多叶受累（75.9%）、外周分布（83.1%）、磨玻璃样混浊（41.0%）、血管边缘增加（63.1%）、长轴平行（55.9%） ，胸膜下有片状磨玻璃影（51.3%）和实变（45.6%）。复查影像学分析显示，改善/稳定组患者较恶化组患者年龄偏小（45.3±15.0 VS. 59.3±13.5，P=0.001）。根据实验室检查结果，影像学阳性的患者年龄较大，46.0（35.0~60.0）VS.31.0（12.0~37.0）P < 0.001，发热的几率更高（P < 0.05）；淋巴细胞、C反应蛋白、红细胞沉降率和乳酸脱氢酶水平较高；白细胞、中性粒细胞和白蛋白水平降低（P < 0.001）。

结论

随着疾病进展，有几个特定的​​图像变化可能有助于早期识别和鉴别诊断 2019 冠状病毒病。对影像特征和实验室测试结果的综合评估可能会提供对 2019 冠状病毒病的完整知识。