Electrostatic self-assembly of pFe3O4 nanoparticles on graphene oxide: A co-dispersed nanosystem reinforces PLLA scaffolds.,Journal of Advanced Research

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Electrostatic self-assembly of pFe3O4 nanoparticles on graphene oxide: A co-dispersed nanosystem reinforces PLLA scaffolds.
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2020-04-22 , DOI: 10.1016/j.jare.2020.04.009
Wenjing Yang _{1,

2} , Yancheng Zhong _{3,

4} , Chongxian He ₁ , Shuping Peng _{3,

4} , Youwen Yang ₁ , Fangwei Qi ₁ , Pei Feng ₂ , Cijun Shuai _{1,

2,

5}

Affiliation

Cell responses and mechanical properties are vital for scaffold in bone regeneration. Fe3O4 nanoparticles with excellent magnetism can provide magnetic stimulation for cell growth, while graphene oxide (GO) nanosheets are commonly used as reinforcement phases due to their high strength. However, Fe3O4 or GO is tended to agglomerate in matrix. In present study, a novel co-dispersed Fe3O4-GO nanosystem was constructed through electrostatic self-assembly of positively charged Fe3O4 (pFe3O4) on negatively charged GO nanosheets. In the nanosystem, pFe3O4 nanoparticles and GO nanosheets support each other, which effectively alleviates the π-π stacking between GO nanosheets and magnetic attraction between pFe3O4 nanoparticles. Subsequently, the nanosystem was incorporated into poly L-lactic acid (PLLA) scaffolds fabricated using selective laser sintering. The results confirmed that the pFe3O4-GO nanosystem exhibited a synergistic enhancement effect on stimulating cell responses by integrating the capturing effect of GO and the magnetic simulation effect of pFe3O4. The activity, proliferation and differentiation of cells grown on scaffolds were significantly enhanced. Moreover, the nanosystem also exhibited a synergistic enhancement effect on mechanical properties of scaffolds, since the pFe3O4 loaded on GO improved the efficiency of stress transfer in matrix. The tensile stress and compressive strength of scaffolds were increased by 67.1% and 132%, respectively. In addition, the nanosystem improved the degradation capability and hydrophilicity of scaffolds.

中文翻译：

pFe3O4 纳米粒子在氧化石墨烯上的静电自组装：一种共分散的纳米系统增强了 PLLA 支架。

细胞反应和机械性能对于骨再生中的支架至关重要。Fe3O4纳米粒子具有优异的磁性，可以为细胞生长提供磁刺激，而氧化石墨烯（GO）纳米片由于其高强度而被普遍用作增强相。然而，Fe3O4 或 GO 倾向于在基体中团聚。在本研究中，通过带正电的 Fe3O4 (pFe3O4) 在带负电的 GO 纳米片上的静电自组装构建了一种新型的共分散 Fe3O4-GO 纳米系统。在纳米体系中，pFe3O4纳米粒子和GO纳米片相互支撑，有效缓解了GO纳米片之间的π-π堆积和pFe3O4纳米粒子之间的磁吸引力。随后，将纳米系统整合到使用选择性激光烧结制造的聚 L-乳酸 (PLLA) 支架中。结果证实，pFe3O4-GO纳米系统通过整合GO的捕获效应和pFe3O4的磁模拟效应，在刺激细胞反应方面表现出协同增强作用。支架上生长的细胞的活性、增殖和分化显着增强。此外，纳米系统还表现出对支架机械性能的协同增强作用，因为负载在 GO 上的 pFe3O4 提高了基质中应力传递的效率。支架的拉应力和抗压强度分别提高了67.1%和132%。此外，纳米系统提高了支架的降解能力和亲水性。

更新日期：2020-04-22

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