Complement system proteins, their regulators and endpoint effector complex significantly promote tumor growth by upregulation of oncogenic growth factors, activation of mitogenic signalling pathways and breakage of normal cell cycle. Contrastingly, complement cascades, initiated by anti-tumor therapeutic antibodies, also play a pivotal role in therapy response. This contradictory role of complement system possibly be a very crucial factor for the outcomes of antibody mediated immunotherapies. Herein, we reviewed the twin role of the complement system in cancer and also the genetic variations in complement system genes. Future studies should be focused on the biomarker discovery for the personalised cancer immunotherapies.

中文翻译：

---

补体系统二分法：肿瘤发生或破坏。

补体系统蛋白，它们的调节剂和终点效应物复合物通过上调致癌生长因子，激活有丝分裂信号通路和破坏正常细胞周期来显着促进肿瘤生长。相反，由抗肿瘤治疗性抗体引发的补体级联反应在治疗反应中也起着关键作用。补体系统的这种相互矛盾的作用可能是抗体介导的免疫治疗结果的关键因素。在本文中，我们回顾了补体系统在癌症中的双重作用以及补体系统基因的遗传变异。未来的研究应集中在针对个性化癌症免疫疗法的生物标志物发现上。