Associations between hepatitis B infection and chronic kidney disease: 10-Year results from the U.S. National Inpatient Sample.,Enfermedades Infecciosas y Microbiología Clínica

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Associations between hepatitis B infection and chronic kidney disease: 10-Year results from the U.S. National Inpatient Sample.
Enfermedades Infecciosas y Microbiología Clínica ( IF 2.6 ) Pub Date : 2020-04-22 , DOI: 10.1016/j.eimc.2020.02.029
Xiao-Xia Geng ₁ , Zhong Tian ₁ , Zhou Liu ₁ , Xue-Mei Chen ₂ , Kai-Ju Xu ₂

Affiliation

Introduction

Viral hepatitis infection is associated with negative impacts on renal function that may lead to nephropathy. We investigated associations between chronic hepatitis B virus (HBV) infection and chronic kidney disease (CKD) and/or end-stage renal disease (ESRD) in a large, representative sample from a nationwide U.S. database.

Methods

This population-based, retrospective observational study extracted data from the U.S. Nationwide Inpatient Sample (NIS) database, including adults ≥18 years old admitted to U.S. hospitals between 2005 and 2014 with records of chronic HBV infection in medical history. The final analytic sample included 70,674 HBV-infected patients and 282,696 matched non-HBV controls. Study endpoints were prevalent CKD and ESRD. Associations between CKD/ESRD and HBV and patients’ clinical characteristics were determined by logistic regression analysis.

Results

HBV infection was associated with slightly increased risk of prevalent CKD (OR: 1.06, 95% CI: 1.004–1.119) and an approximate 2-times risk of prevalent ESRD (OR: 1.98, 95% CI: 1.880–2.086). HBV infection in both genders was associated with slightly increased risk of CKD (males, OR: 1.09, 95% CI: 1.02–1.16; females, OR: 1.07, 95% CI: 0.98,1.17), and significantly associated with increased risk for CKD among non-diabetic patients (OR: 1.23, 95% CI: 1.15–1.32), white patients (OR: 1.14, 95% CI: 1.06–1.23) and Asian/Pacific Islanders (OR: 1.13, 95% CI: 0.98–1.30).

Conclusions

Chronic HBV infection is associated with slightly increased risk for CKD and greater risk for ESRD in males and females, Whites and Asian/Pacific Islanders and non-diabetic patients.

中文翻译：

乙型肝炎感染与慢性肾病之间的关联：来自美国全国住院患者样本的 10 年结果。

介绍

病毒性肝炎感染对可能导致肾病的肾功能产生负面影响。我们在来自美国全国数据库的大型代表性样本中调查了慢性乙型肝炎病毒 (HBV) 感染与慢性肾病 (CKD) 和/或终末期肾病 (ESRD) 之间的关联。

方法

这项基于人群的回顾性观察性研究从美国全国住院患者样本 (NIS) 数据库中提取数据，其中包括 2005 年至 2014 年间在美国医院住院且病史中有慢性 HBV 感染记录的 18 岁以上成年人。最终的分析样本包括 70,674 名 HBV 感染患者和 282,696 名匹配的非 HBV 对照。研究终点是普遍的 CKD 和 ESRD。通过逻辑回归分析确定CKD/ESRD和HBV与患者临床特征之间的关联。

结果

HBV 感染与 CKD 患病风险略有增加有关（OR：1.06，95% CI：1.004–1.119）和 ESRD 患病风险约为 2 倍（OR：1.98，95% CI：1.880–2.086）。两种性别的 HBV 感染都与 CKD 风险略有增加相关（男性，OR：1.09，95% CI：1.02–1.16；女性，OR：1.07，95% CI：0.98,1.17），并且与 CKD 风险增加显着相关非糖尿病患者 (OR: 1.23, 95% CI: 1.15–1.32)、白人患者 (OR: 1.14, 95% CI: 1.06–1.23) 和亚洲/太平洋岛民 (OR: 1.13, 95% CI: 0.98) 的 CKD –1.30）。