Background

This meta-analysis aims to access the efficacy of nasal saline irrigation in the treatment of allergic rhinitis (AR) in adults and children.

Methods

Two authors independently searched databases up to December 2018. Differences in efficacy between saline irrigation and other treatments were compared. Subgroup analyses of discrepancy in effects between children and adults were performed.

Results

(1) Saline irrigation vs. no irrigation, in both children and adults groups, saline irrigation showed significant efficacy. (2) Saline + medication vs. medication, in children group, there was no statistical difference of efficacy between saline + medication and medication; in adults group, efficacy of saline + medicine was superior to that of medication. (3) Saline irrigation vs. medication, in children group, there was no statistical difference between efficacy of saline irrigation and medication; in adults group, efficacy of medication was superior to that of saline irrigation. (4) Hypertonic saline vs. isotonic saline, for children, efficacy of hypertonic saline was superior to that of isotonic saline. Additionally, no adults reported adverse events in all trials. Adverse effects were reported during the first nasal irrigation in 20 children, and one child withdrew due to adverse reactions.

Conclusions

Saline irrigation can significantly improve symptoms of AR in children and adults. Saline irrigation can serve as a safe adjunctive treatment to medication of AR in adults. Saline irrigation can be an alternative therapy for children and pregnant women with AR. Efficacy of hypertonic saline may be better than that of isotonic saline in treating AR of children.

中文翻译：

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鼻腔盐水冲洗在儿童和成人变应性鼻炎治疗中的作用：系统分析。

背景

这项荟萃分析旨在获得鼻腔盐水冲洗在成人和儿童变应性鼻炎（AR）治疗中的功效。

方法

截至2018年12月，两名作者独立搜索数据库。比较了盐水冲洗和其他治疗方法的功效差异。对儿童和成人之间的效果差异进行了亚组分析。

结果

（1）盐水灌溉与不灌溉相比，在儿童和成人组中，盐水灌溉都具有显着的疗效。（2）盐水+药物治疗与药物治疗相比，儿童组生理盐水+药物治疗与药物治疗之间无统计学差异；在成人组，生理盐水+药物的疗效优于药物治疗。（3）盐水冲洗与药物治疗相比，儿童组生理盐水冲洗与药物治疗之间无统计学差异。在成人组中，药物治疗优于盐水冲洗。（4）高渗盐水与等渗盐水相比，对于儿童而言，高渗盐水的疗效优于等渗盐水。此外，在所有试验中，没有成年人报告不良事件。据报道有20名儿童在第一次鼻腔冲洗过程中出现了不良反应，

结论

盐水冲洗可以显着改善儿童和成人的AR症状。盐水冲洗可以作为成人AR药物的安全辅助治疗。盐水冲洗可以作为AR儿童和孕妇的替代疗法。高渗盐水治疗儿童AR的疗效可能优于等渗盐水。