The blood–brain barrier (BBB) is a critical component of the central nervous system that protects neurons and other cells of the brain parenchyma from potentially harmful substances found in peripheral circulation. Gaining a thorough understanding of the development and function of the human BBB has been hindered by a lack of relevant models given significant species differences and limited access to in vivo tissue. However, advances in induced pluripotent stem cell (iPSC) and organ-chip technologies now allow us to improve our knowledge of the human BBB in both health and disease. This review focuses on the recent progress in modeling the BBB in vitro using human iPSCs.

中文翻译：

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人类 iPSC 衍生的血脑屏障模型的最新进展

血脑屏障 (BBB) 是中枢神经系统的重要组成部分，可保护神经元和脑实质的其他细胞免受外周循环中发现的潜在有害物质的侵害。鉴于显着的物种差异和对体内组织的有限访问，缺乏相关模型阻碍了对人类 BBB 的发育和功能的全面了解。然而，诱导多能干细胞 (iPSC) 和器官芯片技术的进步现在使我们能够提高我们对人类 BBB 在健康和疾病方面的了解。本综述重点介绍了使用人类 iPSC 进行体外 BBB 建模的最新进展。