Seasonal and pandemic influenza: 100 years of progress, still much to learn.,Mucosal Immunology

当前位置： X-MOL 学术 › Mucosal Immunol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Seasonal and pandemic influenza: 100 years of progress, still much to learn.
Mucosal Immunology ( IF 7.9 ) Pub Date : 2020-04-21 , DOI: 10.1038/s41385-020-0287-5
Jake Dunning ₁ , Ryan S Thwaites ₂ , Peter J M Openshaw ₂

Affiliation

Influenza viruses are highly transmissible, both within and between host species. The severity of the disease they cause is highly variable, from the mild and inapparent through to the devastating and fatal. The unpredictability of epidemic and pandemic outbreaks is accompanied but the predictability of seasonal disease in wide areas of the Globe, providing an inexorable toll on human health and survival. Although there have been great improvements in understanding influenza viruses and the disease that they cause, our knowledge of the effects they have on the host and the ways that the host immune system responds continues to develop. This review highlights the importance of the mucosa in defence against infection and in understanding the pathogenesis of disease. Although vaccines have been available for many decades, they remain suboptimal in needing constant redesign and in only providing short-term protection. There are real prospects for improvement in treatment and prevention of influenza soon, based on deeper knowledge of how the virus transmits, replicates and triggers immune defences at the mucosal surface.

中文翻译：

季节性和大流行性流感：100 年的进步，仍有很多东西需要学习。

流感病毒在宿主物种内部和宿主物种之间具有高度传播性。它们引起的疾病的严重程度差异很大，从轻微和不明显到毁灭性和致命。流行病和大流行病爆发的不可预测性伴随着全球广大地区季节性疾病的可预测性，对人类健康和生存造成了不可避免的损失。尽管对流感病毒及其引起的疾病的了解有了很大的进步，但我们对它们对宿主的影响以及宿主免疫系统反应方式的了解仍在不断发展。这篇综述强调了粘膜在防御感染和了解疾病发病机制方面的重要性。尽管疫苗已经问世了几十年，但它们仍然不够理想，需要不断重新设计，并且只能提供短期保护。基于对病毒如何传播、复制和触发粘膜表面免疫防御的更深入了解，流感的治疗和预防很快就会得到改善。

更新日期：2020-04-24

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11