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Potential for dehydration to impact the athlete biological passport.
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-05-23 , DOI: 10.1002/dta.2811 Kirsten E Coffman 1 , Katherine M Mitchell 1 , Roy M Salgado 1 , Geoffrey D Miller 2 , Robert W Kenefick 1 , Samuel N Cheuvront 3
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-05-23 , DOI: 10.1002/dta.2811 Kirsten E Coffman 1 , Katherine M Mitchell 1 , Roy M Salgado 1 , Geoffrey D Miller 2 , Robert W Kenefick 1 , Samuel N Cheuvront 3
Affiliation
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In order to inform the Athlete Biological Passport (ABP), this study determined whether the elevation in hemoglobin (Hb) following intracellular or extracellular dehydration would trigger an atypical passport finding (ATPF). Seven male and three female volunteers (age: 23 ± 4 y; height: 170 ± 8 cm; body mass: 78 ± 12 kg) were carefully euhydrated (EUH) to determine baseline Hb levels. Volunteers then completed both an exercise‐induced sweating dehydration (SW) protocol and a diuretic‐induced dehydration (DI) protocol. Dehydration was assessed via body mass changes and Hb was measured via a bench‐top automated hematology analyzer. Using the ABP module, the expected baseline range for each individual was determined using EUH trials, and the impact of each dehydration protocol was then assessed in comparison with these thresholds. Volunteers lost on average 3.1% and 3.7% body mass in the SW and DI trials, respectively. While only one subject exceeded the upper threshold following DI dehydration, six additional subjects demonstrated highly unusual ABP profiles; this was not the case for SW. Sweating is not a feasible explanation for elevated Hb during ABP testing; however, recent illness such as secretory diarrhea, which is mimicked by diuretic administration, may be capable of producing elevated Hb in athletes' biological passports.
中文翻译：
脱水有可能影响运动员的生物护照。
为了告知运动员生物护照（ABP），这项研究确定了细胞内或细胞外脱水后血红蛋白（Hb）的升高是否会触发非典型护照发现（ATPF）。仔细地对七名男性和三名女性志愿者（年龄：23±4岁；身高：170±8 cm；体重：78±12 kg）进行水合（EUH）以确定基线血红蛋白水平。然后，志愿者完成了运动诱发的出汗脱水（SW）方案和利尿剂引起的脱水（DI）方案。通过体重变化评估脱水，并通过台式自动血液分析仪测量血红蛋白。使用ABP模块，使用EUH试验确定每个人的预期基线范围，然后与这些阈值比较评估每种脱水方案的影响。在SW和DI试验中，志愿者平均体重下降了3.1％和3.7％。DI脱水后只有一名受试者超过了上限，另外六名受试者表现出极不寻常的ABP曲线；SW并非如此。出汗不是在ABP测试期间血红蛋白升高的可行解释。但是，最近的疾病，例如分泌性腹泻，可以通过利尿剂来模仿，可能会导致运动员的生物护照中的血红蛋白升高。
更新日期：2020-05-23
中文翻译：
脱水有可能影响运动员的生物护照。
为了告知运动员生物护照（ABP），这项研究确定了细胞内或细胞外脱水后血红蛋白（Hb）的升高是否会触发非典型护照发现（ATPF）。仔细地对七名男性和三名女性志愿者（年龄：23±4岁；身高：170±8 cm；体重：78±12 kg）进行水合（EUH）以确定基线血红蛋白水平。然后，志愿者完成了运动诱发的出汗脱水（SW）方案和利尿剂引起的脱水（DI）方案。通过体重变化评估脱水，并通过台式自动血液分析仪测量血红蛋白。使用ABP模块，使用EUH试验确定每个人的预期基线范围，然后与这些阈值比较评估每种脱水方案的影响。在SW和DI试验中，志愿者平均体重下降了3.1％和3.7％。DI脱水后只有一名受试者超过了上限，另外六名受试者表现出极不寻常的ABP曲线；SW并非如此。出汗不是在ABP测试期间血红蛋白升高的可行解释。但是，最近的疾病，例如分泌性腹泻，可以通过利尿剂来模仿，可能会导致运动员的生物护照中的血红蛋白升高。
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