How can we convert biomarkers into reliable, validated laboratory tests? Glomerular filtration rate (GFR) estimators exist for more than a century. The first utilitarian biomarkers were endogenously produced urea and creatinine. Clinicians then developed simple tests to determine whether or not renal tubular function was maintained. Are there faster and better tests that reflect decreased renal function and increased acute kidney injury (AKI) risk?

中文翻译：

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生物标志物和预测急性肾损伤。

我们如何将生物标志物转化为可靠的、经过验证的实验室测试？肾小球滤过率 (GFR) 估计器已存在一个多世纪。第一个实用生物标志物是内源性产生的尿素和肌酐。临床医生随后开发了简单的测试来确定肾小管功能是否得到维持。是否有更快更好的测试来反映肾功能下降和急性肾损伤 (AKI) 风险增加？