Proton pump inhibitors enhance intestinal permeability via dysbiosis of gut microbiota under stressed conditions in mice.,Neurogastroenterology & Motility

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Proton pump inhibitors enhance intestinal permeability via dysbiosis of gut microbiota under stressed conditions in mice.
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-04-21 , DOI: 10.1111/nmo.13841
Shingo Takashima ₁ , Fumio Tanaka ₁ , Yunosuke Kawaguchi ₂ , Yuki Usui ₃ , Kosuke Fujimoto _{2,

4} , Yuji Nadatani ₁ , Koji Otani ₁ , Shuhei Hosomi ₁ , Yasuaki Nagami ₁ , Noriko Kamata ₁ , Koichi Taira ₁ , Tetsuya Tanigawa ₁ , Toshio Watanabe ₁ , Seiya Imoto ₅ , Satoshi Uematsu _{2,

4} , Yasuhiro Fujiwara ₁

Affiliation

Intestinal permeability and psychological stress are considered the key mechanism(s) in functional dyspepsia (FD). Although proton pump inhibitors (PPIs) are commonly used for the treatment of FD, the effect of PPIs on intestinal permeability has not been elucidated. This study investigated the effect of PPI on intestinal permeability under stressed conditions.

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