The treatment of spinal muscular atrophy (SMA) with nusinersen requires intrathecal medication administration, which can be challenging in individuals with complicated spines. This retrospective case series reviews the nusinersen treatment experience at one academic medical center with children and adults with SMA and complicated spines.

中文翻译：

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在棘突复杂的个体中鞘内递送nusinersen。

用nusinersen治疗脊髓性肌萎缩症（SMA）需要鞘内注射药物，这对于棘突复杂的患者可能具有挑战性。该回顾性病例系列回顾了在一个学术医疗中心接受SMA和复杂棘突的儿童和成人所接受的Nusinersen治疗经验。