In this study, we investigated computationally and experimentally a hexagonal‐pattern array of spatially fractionated proton minibeams produced by proton pencil beam scanning (PBS) technique. Spatial fractionation of dose delivery with millimeter or submillimeter beam size has proven to be a promising approach to significantly increase the normal tissue tolerance. Our goals are to obtain an optimized minibeam design and to show that it is feasible to implement the optimized minibeams at the existing proton clinics.

中文翻译：

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使用质子束扫描进行空间分割放疗的六边形小光束的优化。

在这项研究中，我们计算和实验研究通过质子产生的在空间上分馏质子minibeams的六边形图案阵列p encil b EAM小号装罐（PBS）的技术。已经证明，以毫米或亚毫米光束尺寸对剂量输送进行空间分级是一种显着提高正常组织耐受性的有前途的方法。我们的目标是获得优化的微束设计，并表明在现有质子诊所中实施优化的微束是可行的。