Due to increasing demands for ecofriendly processes within the framework of green chemistry, and having shown substantial properties, especially in terms of toxicity, biodegradability, cost, and ease of preparation under ambient conditions, deep eutectic solvents (DESs) have become a suitable candidate as green solvents for reaction media in the past decade. In this work, condensation reaction of some para‐ and meta‐substituted benzaldehydes and Malononitrile was kinetically investigated in ethylene glycol‐choline chloride (ethaline) as a DES mixed with water, in the whole range of mole fractions, at room temperature. The correlation of second‐order rate coefficients based on Hammett's substituent constants yield a linear straight line with positive slope in different mole fractions of ethaline–water mixtures. The measured second‐order rate coefficients of the reaction showed a dramatic variation in ethaline–water mixtures with the increasing mole fraction of water.

中文翻译：

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乙醛作为深共熔溶剂的水溶液中丙二腈与取代的苯甲醛的反应动力学研究

由于在绿色化学框架内对环保工艺的需求不断增加，并且已显示出显着的性能，尤其是在毒性，生物降解性，成本和在环境条件下易于制备方面，深共熔溶剂（DES）已成为适合的候选材料。在过去十年中用作反应介质的绿色溶剂。在这项工作中，在室温下，在摩尔比整个范围内的乙二醇-胆碱氯化物（乙胺）中，DES与水混合，动力学研究了一些对位和间位取代的苯甲醛与丙二腈的缩合反应。基于Hammett取代基常数的二阶速率系数的相关性在不同的乙醇/水混合物摩尔分数中产生具有正斜率的线性直线。