Ventromedial regions of the frontal lobe (vmFL) are thought to play a key role in decision‐making and emotional regulation. However, aspects of this area's functional organization, including the presence of a multiple subregions, their functional and anatomical connectivity, and the cross‐species homologies of these subregions with those of other species, remain poorly understood. To address this uncertainty, we employed a two‐stage parcellation of the region to identify six distinct structures within the region on the basis of data‐driven classification of functional connectivity patterns obtained using the meta‐analytic connectivity modeling (MACM) approach. From anterior to posterior, the derived subregions included two lateralized posterior regions, an intermediate posterior region, a dorsal and ventral central region, and a single anterior region. The regions were characterized further by functional connectivity derived using resting‐state fMRI and functional decoding using the Brain Map database. In general, the regions could be differentiated on the basis of different patterns of functional connectivity with canonical “default mode network” regions and/or subcortical regions such as the striatum. Together, the findings suggest the presence of functionally distinct neural structures within vmFL, consistent with data from experimental animals as well prior demonstrations of anatomical differences within the region. Detailed correspondence with the anterior cingulate, medial orbitofrontal cortex, and rostroventral prefrontal cortex, as well as specific animal homologs are discussed. The findings may suggest future directions for resolving potential functional and structural correspondence of subregions within the frontal lobe across behavioral contexts, and across mammalian species.

中文翻译：

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人类腹内侧额叶的功能分化：数据驱动的分割。

额叶腹内侧区 (vmFL) 被认为在决策和情绪调节中起着关键作用。然而，该区域功能组织的各个方面，包括多个子区域的存在、它们的功能和解剖学连通性，以及这些子区域与其他物种的跨物种同源性，仍然知之甚少。为了解决这种不确定性，我们基于使用元分析连接建模 (MACM) 方法获得的功能连接模式的数据驱动分类，对该区域进行了两阶段分割，以识别该区域内的六个不同结构。从前到后，衍生的亚区包括两个侧化后区，一个中间后区，一个背中央区和腹中央区，和一个单一的前部区域。通过使用静息状态 fMRI 和使用脑图数据库的功能解码得出的功能连接进一步表征这些区域。一般来说，这些区域可以根据与典型“默认模式网络”区域和/或皮层下区域（如纹状体）的不同功能连接模式进行区分。总之，这些发现表明 vmFL 内存在功能不同的神经结构，这与来自实验动物的数据以及该区域内解剖学差异的先前证明一致。讨论了与前扣带回、内侧眶额叶皮层和 rostroventral 前额叶皮层的详细对应关系，以及特定的动物同源物。