Behavioral evidence of impaired response inhibition (RI) and hyperactive error monitoring (EM) in obsessive-compulsive disorder (OCD) is inconsistent. Recent neuroimaging work suggests that EM plays a role in RI impairments in OCD, but this has rarely been investigated using behavioral measures. The aims of this study were to (1) compare RI and EM performance between adults with OCD and non-psychiatric controls (NPC) while investigating possible moderators, and (2) assess whether excessive EM influences RI in OCD. We compared RI and EM performance on the Stop-Signal Task (SST) between 92 adults with OCD and 65 NPC from two Brazilian sites. We used linear regression to investigate which variables (group, age, medication use, clinical symptomatology) influenced performance, as well as to examine possible associations between RI and EM. OCD and NPC did not differ in RI and EM. However, age moderated RI performance in OCD with a medium effect size, reflecting differential effects of age on RI between groups: age was positively associated with RI in OCD but not NPC. Further, OCD severity predicted EM with a medium to large effect size, suggesting that more symptomatic patients showed greater monitoring of their mistakes. Finally, group moderated the relationship between RI and EM with a small effect size. Our findings suggest that demographic factors may influence RI, whereas clinical factors may influence EM. Further, we found preliminary behavioral evidence to indicate that impaired RI and excessive EM are related in OCD.

中文翻译：

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探索强迫症的反应抑制和错误监测。

强迫症（OCD）中反应抑制（RI）和过度活动错误监测（EM）受损的行为证据不一致。最近的神经影像研究表明，EM在强迫症的RI损伤中起一定作用，但很少使用行为学方法对此进行研究。这项研究的目的是（1）在调查可能的主持人的同时，比较患有强迫症的成人和非精神病控制者（NPC）的RI和EM表现，以及（2）评估过量的EM是否会影响OCD的RI。我们比较了来自两个巴西站点的92位OCD和65位NPC成年人在停止信号任务（SST）上的RI和EM性能。我们使用线性回归来研究哪些变量（组，年龄，药物使用，临床症状）影响了表现，并检查了RI和EM之间的可能关联。OCD和NPC在RI和EM方面没有差异。然而，OCD的适度RI表现具有中等程度的影响，反映出年龄对两组间RI的不同影响：OCD的年龄与RI呈正相关，而NPC与RI呈正相关。此外，OCD严重程度可预测EM，其影响程度为中到大，这表明更多有症状的患者对自己的错误表现出更大的监控。最后，小组以较小的影响量缓和了RI和EM之间的关系。我们的发现表明，人口统计学因素可能会影响RI，而临床因素可能会影响EM。此外，我们发现初步的行为证据表明，OCD与RI受损和EM过多有关。年龄与强迫症中的RI呈正相关，但与NPC无关。此外，OCD的严重程度可预测EM的影响范围为中到大，这表明更多有症状的患者表现出对错误的更好监测。最后，小组以较小的影响量缓和了RI和EM之间的关系。我们的发现表明，人口统计学因素可能会影响RI，而临床因素可能会影响EM。此外，我们发现初步的行为证据表明，OCD与RI受损和EM过多有关。年龄与强迫症中的RI呈正相关，但与NPC无关。此外，OCD的严重程度可预测EM的影响范围为中到大，这表明更多有症状的患者表现出对错误的更好监测。最后，小组以较小的影响量缓和了RI和EM之间的关系。我们的发现表明，人口统计学因素可能会影响RI，而临床因素可能会影响EM。此外，我们发现初步的行为证据表明，OCD与RI受损和EM过多有关。我们的发现表明，人口统计学因素可能会影响RI，而临床因素可能会影响EM。此外，我们发现初步的行为证据表明，OCD与RI受损和EM过多有关。我们的发现表明，人口统计学因素可能会影响RI，而临床因素可能会影响EM。此外，我们发现初步的行为证据表明，OCD与RI受损和EM过多有关。