The most common form of polycystic kidney disease (PKD) in humans is caused by mutations in the PKD1 gene coding for polycystin1 (PC1). Among the many identified or proposed functions of PC1 is its ability to regulate the activity of transcription factors of the STAT family. Most STAT proteins that have been investigated were found to be aberrantly activated in kidneys in PKD, and some have been shown to be drivers of disease progression. In this review, we focus on the role of signal transducer and activator of transcription (STAT) signaling pathways in various renal cell types in healthy kidneys as compared to polycystic kidneys, on the mechanisms of STAT regulation by PC1 and other factors, and on the possibility to target STAT signaling for PKD therapy.

中文翻译：

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多囊肾病中的 STAT 信号传导。

人类最常见的多囊肾病 (PKD) 是由编码多囊蛋白 1 (PC1) 的 PKD1 基因突变引起的。PC1 的许多已识别或提议的功能之一是其调节 STAT 家族转录因子活性的能力。大多数已研究的 STAT 蛋白被发现在 PKD 患者的肾脏中异常激活，其中一些已被证明是疾病进展的驱动因素。在这篇综述中，我们重点关注与多囊肾相比，健康肾脏中各种肾细胞类型中信号转导子和转录激活子 (STAT) 信号通路的作用，PC1 和其他因子调节 STAT 的机制，以及靶向 STAT 信号传导用于 PKD 治疗的可能性。