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Genomic characterization of a novel virulent phage infecting Shigella fiexneri and isolated from sewage.
Virus Research ( IF 2.5 ) Pub Date : 2020-04-20 , DOI: 10.1016/j.virusres.2020.197983
Han Lu 1 , Peihan Yan 1 , Wenbin Xiong 1 , Jingwei Wang 1 , Xinchun Liu 1
Affiliation  

Shigella fiexneri phage SGF2 is a novel lytic phage isolated from a sewage sample. Morphological characterization indicates that phage SGF2 is a member of the Podoviridae family, producing virions with an isometric head (82.6 ± 8 nm diameter) and a short non-contractile tail (length 52 ± 8 nm). This phage specifically infected the Shigella fiexneri. One-step growth curves indicated that the burst period of phage SGF2 is 30 min, with an approximate burst size of 38. The full-length genome was sequenced and potential virulence genes were detected. We will discuss the potential application of phage SGF2 in phage therapy.

中文翻译:

感染 Shigella fiexneri 并从污水中分离的新型毒力噬菌体的基因组特征。

Shigella fiexneri 噬菌体 SGF2 是一种从污水样品中分离出来的新型裂解噬菌体。形态学特征表明噬菌体 SGF2 是 Podoviridae 家族的成员,产生具有等距头部(直径 82.6 ± 8 nm)和短的非收缩尾(长度 52 ± 8 nm)的病毒粒子。这种噬菌体专门感染了志贺氏菌。一步生长曲线表明噬菌体SGF2的爆发期为30 min,爆发期约为38。对全长基因组进行测序并检测到潜在的毒力基因。我们将讨论噬菌体 SGF2 在噬菌体治疗中的潜在应用。
更新日期:2020-04-22
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