Intolerable toxicity and unsatisfactory therapeutic effects are still big problems retarding the use of chemotherapy against cancer. Nano-drug delivery system promised a lot in increasing the patients’ compliance and therapeutic efficacy. As a unique nano-carrier, supermolecular aggregation nanovehicle has attracted increasing interests due to the following advantages: announcing drug loading efficacy, pronouncing in vivo performance and simplified production process. In this study, the supermolecular aggregation nanovehicle of bortezomib (BTZ) was prepared to treat breast cancer. Although many supermolecular nanovehicles are inclined to disintegrate due to the weak intermolecular interactions among the components, the BTZ supermolecules are satisfying stable. To shed light on the reasons behind this, the forces driving the formation of the nanovehicles were detailed investigated. In other words, the interactions among BTZ and other two components were studied to characterize the nanovehicles and ensure its stability. Due to the promising tumor targeting ability of the BTZ nanovehicles, the supermolecule displayed promising tumor curing effects and negligible systemic toxicity.

中文翻译：

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硼替佐米超分子聚集纳米载体的制备，表征及体外评价

难以忍受的毒性和不令人满意的治疗效果仍然是阻碍化学疗法治疗癌症的主要问题。纳米药物输送系统有望提高患者的依从性和治疗功效。作为一种独特的纳米载体，超分子聚集纳米载体由于以下优点而引起了越来越多的关注：宣布载药功效，宣布体内性能和简化生产工艺。在这项研究中，制备了硼替佐米（BTZ）的超分子聚集纳米载体以治疗乳腺癌。尽管由于组分之间的弱分子间相互作用，许多超分子纳米车辆倾向于崩解，但是BTZ超分子令人满意。为了阐明其背后的原因，详细研究了驱动纳米车辆形成的力。换句话说，研究了BTZ与其他两个组件之间的相互作用，以表征纳米车辆并确保其稳定性。由于BTZ纳米车辆的有希望的肿瘤靶向能力，该超分子显示出有希望的肿瘤治愈作用和可忽略的全身毒性。