BACKGROUND Previous studies found that Ser9Gly (rs6280) might be involved in the occurrence of schizophrenia. However, no consist conclusion has yet been achieved. Compared to the case-control study, the family-based study took into account stratification bias. Thus, we conducted a meta-analysis of family-based studies to measure a pooled effect size of the association between Ser9Gly and the risk of schizophrenia. METHODS The relevant family-based studies were screened using the electronic databases by the inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to measure the correction between Ser9Gly polymorphism and schizophrenia susceptibility. Subgroup analysis was performed by stratification of ethnicity (i.e., East Asian, Caucasian, and other populations). Additionally, publication bias was evaluated by the funnel plot. RESULTS After literature searching, a total of 13 family-based association studies were included, which contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HRR) studies. No statistical significance of the heterogeneity was detected in TDT and HRR studies. Thus, the pooled effect size was calculated under the fixed effect model. The results found that the association was significantly protective in East Asian in TDT studies (204 informative meiosis, OR = 0.744, 95% CI = 0.564-0.980, Z-value = - 2.104, p = 0.035). CONCLUSIONS The meta-analysis based on the family study found a protective association of Ser9Gly in East Asian. In future, large sample molecular epidemiology studies are needed to validate our findings.

中文翻译：

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多巴胺受体D3基因的Ser9Gly多态性与精神分裂症之间没有关联：基于家庭的关联研究的荟萃分析。

背景技术以前的研究发现，Ser9Gly（rs6280）可能与精神分裂症的发生有关。但是，尚无一致结论。与病例对照研究相比，基于家庭的研究考虑了分层偏差。因此，我们对基于家庭的研究进行了荟萃分析，以评估Ser9Gly与精神分裂症风险之间关联的合并效应量。方法采用纳入标准，使用电子数据库筛选相关的基于家庭的研究。赔率（OR）和95％置信区间（CI）用于衡量Ser9Gly多态性与精神分裂症易感性之间的校正。通过种族分层（即东亚，白种人和其他人口）进行亚组分析。另外，通过漏斗图评估出版偏倚。结果经过文献检索，总共包括13个基于家庭的关联研究，其中包括11个传播不平衡测试（TDT）研究，1219个信息减数分裂和5个基于单体型的单体型相对风险（HRR）研究。在TDT和HRR研究中未检测到异质性的统计学意义。因此，在固定效果模型下计算了合并效果大小。结果发现，该关联在TDT研究中对东亚地区具有显着保护作用（204信息性减数分裂，OR = 0.744，95％CI = 0.564-0.980，Z值=-2.104，p = 0.035）。结论基于家族研究的荟萃分析发现，Ser9Gly在东亚地区具有保护性关联。在未来，