Abstract

Plant-associated endophytic fungi are rich sources of novel bioactive and structurally diverse secondary metabolites and other natural products. Newly synthesized secondary metabolites of endophytes in terrestrial plants and their biological properties are presented and reviewed herein. The review highlights natural products from plant-associated fungal endophytes that demonstrate significant inhibition against pathogenic strains, human cancer cell lines and other biological targets. We have summarized 221 recently isolated, structurally diverse and novel secondary metabolites. Secondary metabolites that failed to demonstrate activity in the bioassays are not included. The review is intended to assist scientists in the fields of phytochemistry, organic chemistry, and pharmacology.

Graphic abstract

中文翻译：

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内生真菌的新型次生代谢产物：合成与生物学特性

摘要

与植物相关的内生真菌是新型生物活性和结构多样的次生代谢产物和其他天然产物的丰富来源。本文介绍和综述了陆生植物中内生菌的新合成次生代谢产物及其生物学特性。该综述重点介绍了来自植物相关真菌内生菌的天然产物，这些产物对病原菌株，人类癌细胞系和其他生物靶标具有显着抑制作用。我们总结了221个最近分离的，结构多样的新型次生代谢产物。不包括未能在生物测定中证明其活性的次生代谢产物。该综述旨在协助植物化学，有机化学和药理学领域的科学家。

图形摘要