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An MRI-compatible varus-valgus loading device for whole-knee joint functionality assessment based on compartmental compression: a proof-of-concept study.
Magnetic Resonance Materials in Physics Biology and Medicine ( IF 2.0 ) Pub Date : 2020-04-20 , DOI: 10.1007/s10334-020-00844-6
Oliver Said 1 , Justus Schock 2, 3 , Nils Krämer 1 , Johannes Thüring 1 , Lea Hitpass 1 , Philipp Schad 1 , Christiane Kuhl 1 , Daniel Abrar 2 , Daniel Truhn 1, 3 , Sven Nebelung 2
Affiliation  

OBJECTIVE Beyond static assessment, functional techniques are increasingly applied in magnetic resonance imaging (MRI) studies. Stress MRI techniques bring together MRI and mechanical loading to study knee joint and tissue functionality, yet prototypical axial compressive loading devices are bulky and complex to operate. This study aimed to design and validate an MRI-compatible pressure-controlled varus-valgus loading device that applies loading along the joint line. METHODS Following the device's thorough validation, we demonstrated proof of concept by subjecting a structurally intact human cadaveric knee joint to serial imaging in unloaded and loaded configurations, i.e. to varus and valgus loading at 7.5 kPa (= 73.5 N), 15 kPa (= 147.1 N), and 22.5 kPa (= 220.6 N). Following clinical standard (PDw fs) and high-resolution 3D water-selective cartilage (WATSc) sequences, we performed manual segmentations and computations of morphometric cartilage measures. We used CT and radiography (to quantify joint space widths) and histology and biomechanics (to assess tissue quality) as references. RESULTS We found (sub)regional decreases in cartilage volume, thickness, and mean joint space widths reflective of areal pressurization of the medial and lateral femorotibial compartments. DISCUSSION Once substantiated by larger sample sizes, varus-valgus loading may provide a powerful alternative stress MRI technique.

中文翻译:

基于隔室压缩的全膝关节功能评估的 MRI 兼容内翻-外翻加载装置:概念验证研究。

目标除了静态评估,功能技术越来越多地应用于磁共振成像 (MRI) 研究。应力 MRI 技术将 MRI 和机械载荷结合起来研究膝关节和组织功能,但典型的轴向压缩载荷装置体积庞大且操作复杂。本研究旨在设计和验证一种与 MRI 兼容的压力控制内翻外翻加载装置,该装置沿关节线施加加载。方法 在对设备进行彻底验证之后,我们通过对结构完整的人体膝关节进行无负载和负载配置的连续成像,即在 7.5 kPa (= 73.5 N)、15 kPa (= 147.1) 下进行内翻和外翻加载来证明概念验证N) 和 22.5 kPa (= 220.6 N)。遵循临床标准 (PDw fs) 和高分辨率 3D 水选择性软骨 (WATSc) 序列,我们对形态测量软骨测量进行了手动分割和计算。我们使用 CT 和放射照相术(量化关节间隙宽度)以及组织学和生物力学(评估组织质量)作为参考。结果我们发现软骨体积、厚度和平均关节间隙宽度的(亚)区域减少反映了内侧和外侧股胫隔室的区域加压。讨论 一旦得到更大样本量的证实,内翻外翻负荷可能会提供一种强大的替代应力 MRI 技术。我们使用 CT 和放射照相术(量化关节间隙宽度)以及组织学和生物力学(评估组织质量)作为参考。结果我们发现软骨体积、厚度和平均关节间隙宽度的(亚)区域减少反映了内侧和外侧股胫隔室的区域加压。讨论 一旦得到更大样本量的证实,内翻外翻负荷可能会提供一种强大的替代应力 MRI 技术。我们使用 CT 和放射照相术(量化关节间隙宽度)以及组织学和生物力学(评估组织质量)作为参考。结果我们发现软骨体积、厚度和平均关节间隙宽度的(亚)区域减少反映了内侧和外侧股胫隔室的区域加压。讨论 一旦得到更大样本量的证实,内翻外翻负荷可能会提供一种强大的替代应力 MRI 技术。
更新日期:2020-04-22
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