Metal-based therapies (e.g. Vanadium) possess an attractive proposition in medicinal treatment of diabetes mellitus. Defective insulin secretion can result from impaired β-cell function which is mediated by many process including apoptosis and autophagy. In this study. diabetes was induced by administration of streptozotocin then treatment was performed by vanadyl sulfate and [VO(bpy)2 Cl] Cl.H2O complex. Blood glucose level, AST, ALT, BUN, CR, TCHO, TG and total protein were determined in serum. MDA, NO, erythrocyte GSH and SOD were estimated. LC3 and Caspase 3 levels in pancreatic cells were assessed by flow cytometer. Histopathological investigation of pancreatic tissue was performed. Results of Diabetic group showed a significant increase in transaminases activities, TCHO, TG, MDA, NO and Caspase 3 levels and significant decrease in TP, GSH, SOD and LC3 levels. Oral administration of vanadium complex resulted in normoglycemia, significant increase in blood GSH, SOD, TP and LC3 levels, significant decrease in ALT, AST, BUN, TCHO, TG, MDA and NO and Caspase 3 levels. In addition, proliferative effect of complex prevents islet atrophy. From previous results, the insulin-enhancing effect induced by this complex indicated that this new complex can be a valuable candidate as insulin-enhancing and antioxidant compound than inorganic vanadyl sulfate.

中文翻译：

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凋亡和自噬在链脲佐菌素诱导的糖尿病小鼠中氧钒（IV）联吡啶复合物的胰岛素增强活性中的作用。

金属基疗法（例如钒）在糖尿病的药物治疗中具有有吸引力的主张。胰岛素分泌缺陷可能是由β细胞功能受损引起的，β细胞功能受损是由许多过程介导的，包括凋亡和自噬。在这个研究中。服用链脲佐菌素可诱发糖尿病，然后用硫酸氧钒和[VO（bpy）2 Cl] Cl.H2O复合物进行治疗。测定血清中的血糖水平，AST，ALT，BUN，CR，TCHO，TG和总蛋白。估算MDA，NO，红细胞GSH和SOD。用流式细胞仪评估胰腺细胞中的LC3和Caspase 3水平。进行了胰腺组织的组织病理学研究。糖尿病组的结果显示转氨酶活性，TCHO，TG，MDA，NO和Caspase 3水平显着增加，而TP，GSH显着下降。SOD和LC3含量。口服钒配合物可导致血糖正常，血液中GSH，SOD，TP和LC3水平显着升高，ALT，AST，BUN，TCHO，TG，MDA和NO和Caspase 3水平显着降低。此外，复合物的增殖作用可防止胰岛萎缩。从以前的结果来看，这种复合物诱导的胰岛素增强作用表明，与无机硫酸氧钒相比，这种新的复合物可以作为胰岛素增强和抗氧化剂化合物的有价值的候选者。