Ions transiting biomembranes might pass readily from water through ion-specific membrane proteins if these protein channels provide environments similar to the aqueous solution hydration environment. Indeed, bulk aqueous solution is an important reference condition for the ion permeation process. Assessment of this hydration mimicry concept depends on understanding the hydration structure and free energies of metal ions in water in order to provide a comparison for the membrane channel environment. To refine these considerations, we review local hydration structures of ions in bulk water and the molecular quasi-chemical theory that provides hydration free energies. In doing so, we note some current views of ion binding to membrane channels and suggest new physical chemical calculations and experiments that might further clarify the hydration mimicry concept.

中文翻译：

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膜离子通道的水化模拟。

如果这些离子通道提供的水溶液与水溶液水合环境相似，则离子迁移生物膜可能会很容易从水中通过离子特异性膜蛋白。实际上，大量水溶液是离子渗透过程的重要参考条件。对这种水合模仿概念的评估取决于对水中金属离子的水合结构和自由能的了解，以便对膜通道环境进行比较。为了完善这些考虑因素，我们回顾了散装水中离子的局部水合结构以及提供水合自由能的分子准化学理论。在这样做，