The aim was to evaluate the clinical impact of IGF-1/IGF-1R in Tunisian laryngeal carcinoma. A high IGF-1R immunohistochemical expression was found in our series (81.43%). A tendency toward an association between IGF-1R expression and lymph node metastasis was found (p = 0.068). Patients with positive IGF-1R expression showed a short disease free survival (p = 0.053) and a high recurrence rate. Furthermore, circulating IGF-1 levels sera, detected by ELISA, were higher among patients compared to controls (p < 0.001). IGF-1R might have a prognostic significance and could be a factor of tumor recurrence. However, high levels of IGF-1 increase the risk of developing of LSCC disease.

目的是评估IGF-1 / IGF-1R在突尼斯喉癌中的临床影响。在我们的系列中发现了较高的IGF-1R免疫组织化学表达（81.43％）。发现IGF-1R表达与淋巴结转移之间有关联的趋势（p  = 0.068）。IGF-1R表达阳性的患者表现出无疾病生存期短（p  = 0.053）和高复发率。此外，与对照组相比，通过ELISA检测到的患者中循环IGF-1水平血清更高（p  <0.001）。IGF-1R可能具有预后意义，并且可能是肿瘤复发的因素。但是，高水平的IGF-1会增加患LSCC疾病的风险。