Conceptual knowledge is supported by multiple semantic systems that are specialized for the analysis of different properties associated with object concepts. Various types of semantic association between concrete concepts-categorical (CA), encyclopedic (EA), functional (FA), and visual-encyclopedic (VEA) associations-were tested through a new picture-to-picture matching task (semantic association task, SAT). Forty individuals with Alzheimer's disease (AD), 13 with behavioral variant of frontotemporal dementia (bv-FTD), 6 with primary progressive aphasia (PPA), and 37 healthy participants were tested with the SAT. Within-group comparisons highlighted a global impairment of all types of semantic association in bv-FTD individuals but a disproportionate impairment of EA and FA, with relative sparing of CA and VEA, in AD individuals. Single-case analyses detected dissociations in all dementia groups. Conceptual knowledge can be selectively impaired in various types of neurodegenerative disease on the basis of the specific cognitive process that is disrupted.

中文翻译：

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通过痴呆症患者的语义关联任务评估语义知识。


概念知识由多个语义系统支持，这些语义系统专门用于分析与对象概念相关的不同属性。通过新的图片到图片匹配任务（语义关联任务， SAT）。 40 名阿尔茨海默病 (AD) 患者、13 名额颞叶痴呆行为变异型 (bv-FTD) 患者、6 名原发性进行性失语症 (PPA) 患者和 37 名健康参与者接受了 SAT 测试。组内比较突显了 bv-FTD 个体中所有类型语义关联的整体损害，但 AD 个体中 EA 和 FA 的损害不成比例，而 CA 和 VEA 相对较少。单病例分析发现所有痴呆症组都存在分离现象。基于被破坏的特定认知过程，概念性知识可能在各种类型的神经退行性疾病中选择性受损。