Glioblastoma (GBM) consists of devastating neoplasms with high invasive capacity, which have been difficult to study in vitro in a human-derived model system. Therapeutic progress is also limited by cellular heterogeneity within and between tumors, among other factors such as therapy resistance. To address these challenges, we present an experimental model using human cerebral organoids as a scaffold for patient-derived GBM cell invasion.

中文翻译：

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使用人脑类器官和单细胞转录组学建模胶质母细胞瘤侵袭。

胶质母细胞瘤（GBM）由具有高侵袭能力的毁灭性肿瘤组成，很难在人源模型系统中进行体外研究。除其他因素例如治疗抗性外，治疗进展还受到肿瘤内部和之间的细胞异质性的限制。为了解决这些挑战，我们提出了一种使用人脑类器官作为患者源性GBM细胞入侵支架的实验模型。