It is now evident that transcriptional gene regulation usually requires the re-organization of chromatin architecture. Increasing evidence suggested various kinds of RNAs are involved in this process. Especially the nascent RNAs retained at their site of transcription can serve as a scaffold for organizing transcriptionally either favorable or unfavorable chromatin structures. An emerging concept of phase separation explains how these chromatin structures can be maintained as physically discrete subcompartments within membrane-less nucleoplasm. Evidences that support the crucial role of nascent RNAs in the formation of phase-separated condensates are now rapidly growing.

中文翻译：

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RNA介导的染色质结构调节。

现在很明显，转录基因调控通常需要重组染色质结构。越来越多的证据表明各种RNA参与了这一过程。尤其是保留在其转录位点的新生RNA可以充当支架，用于在组织上组织有利或不利的染色质结构。相分离的新兴概念解释了如何在无膜核质中将染色质结构作为物理上不连续的小室进行维护。支持新生RNA在相分离冷凝物形成中的关键作用的证据现在正在迅速增长。