In vitro modeling of glioblastoma initiation using PDGF-AA and p53-null neural progenitors.,Neuro-Oncology

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In vitro modeling of glioblastoma initiation using PDGF-AA and p53-null neural progenitors.
Neuro-Oncology ( IF 15.9 ) Pub Date : 2020-04-16 , DOI: 10.1093/neuonc/noaa093
Alexandra K Bohm _{1,

2} , Jessica DePetro _{1,

2} , Carmen E Binding _{1,

2} , Amanda Gerber _{1,

2} , Nicholas Chahley _{1,

2} , N Dan Berger _{1,

2} , Mathaeus Ware _{1,

2} , Kaitlin Thomas _{1,

2} , U Senapathi _{1,

2} , Shazreh Bukhari _{1,

2} , Cindy Chen _{1,

2} , Erin Chahley _{1,

2} , Cameron Grisdale ₃ , Sam Lawn _{1,

2} , Yaping Yu ₂ , Raymond Wong ₄ , Yaoqing Shen ₅ , Hiba Omairi _{1,

2} , Reza Mirzaei _{1,

3} , Nourah Alshatti _{1,

2} , Haley Pedersen _{1,

2} , Wee Yong _{1,

2,

3} , Samuel Weiss _{1,

2,

3} , Jennifer Chan _{1,

2,

3} , P J Cimino ₆ , John Kelly _{1,

2,

3} , Steve Jones ₅ , Eric Holland ₆ , Michael Blough _{1,

2} , Gregory Cairncross _{1,

2,

5}

Affiliation

Imagining ways to prevent or treat glioblastoma (GBM) has been hindered by a lack of understanding of its pathogenesis. Although overexpression of platelet derived growth factor with two A-chains (PDGF-AA) may be an early event, critical details of the core biology of GBM are lacking. For example, existing PDGF-driven models replicate its microscopic appearance, but not its genomic architecture. Here we report a model that overcomes this barrier to authenticity.

中文翻译：

使用PDGF-AA和p53-null神经祖细胞对胶质母细胞瘤的体外建模。

缺乏对胶质母细胞瘤发病机理的了解，阻碍了预防或治疗胶质母细胞瘤（GBM）的方法。尽管具有两个A链的血小板衍生生长因子（PDGF-AA）的过表达可能是早期事件，但仍缺乏GBM核心生物学的关键细节。例如，现有的PDGF驱动的模型可以复制其微观外观，但不能复制其基因组架构。在这里，我们报告了一种克服了真实性障碍的模型。

更新日期：2020-04-16

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