Background It has been suggested that polymorphisms within CYP1A2 impact inter-individual variation in the response to caffeine. The purpose of this study was to explore the acute effects of caffeine on resistance exercise, jumping, and sprinting performance in a sample of resistance-trained men, and to examine the influence of genetic variation of CYP1A2 (rs762551) on the individual variation in responses to caffeine ingestion. Methods Twenty-two men were included as participants (AA homozygotes n = 13; C-allele carriers n = 9) and were tested after the ingestion of caffeine (3 mg/kg of body mass) and a placebo. Exercise performance was assessed with the following outcomes: (a) movement velocity and power output in the bench press exercise with loads of 25, 50, 75, and 90% of one-repetition maximum (1RM); (b) quality and quantity of performed repetitions in the bench press exercise performed to muscular failure with 85% 1RM; (c) vertical jump height in a countermovement jump test; and (d) power output in a Wingate test. Results Compared to placebo, caffeine ingestion enhanced: (a) movement velocity and power output across all loads (effect size [ES]: 0.20–0.61; p < 0.05 for all); (b) the quality and quantity of performed repetitions with 85% of 1RM (ES: 0.27–0.85; p < 0.001 for all); (c) vertical jump height (ES: 0.15; p = 0.017); and (d) power output in the Wingate test (ES: 0.33–0.44; p < 0.05 for all). We did not find a significant genotype × caffeine interaction effect ( p -values ranged from 0.094 to 0.994) in any of the analyzed performance outcomes. Conclusions Resistance-trained men may experience acute improvements in resistance exercise, jumping, and sprinting performance following the ingestion of caffeine. The comparisons of the effects of caffeine on exercise performance between individuals with the AA genotype and AC/CC genotypes found no significant differences. Trial registration Australian New Zealand Clinical Trials Registry. ID: ACTRN12619000885190 .

中文翻译：

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CYP1A2 基因型和咖啡因对抗阻运动、跳跃和短跑表现的急性影响

背景 有人提出 CYP1A2 内的多态性影响对咖啡因反应的个体间差异。本研究的目的是探讨咖啡因对抗阻训练男性样本的抗阻运动、跳跃和短跑表现的急性影响，并检查 CYP1A2 (rs762551) 的遗传变异对个体反应变异的影响摄入咖啡因。方法 包括 22 名男性作为参与者（AA 纯合子 n = 13；C 等位基因携带者 n = 9），并在摄入咖啡因（3 毫克/千克体重）和安慰剂后进行测试。运动表现通过以下结果进行评估：(a) 卧推运动中的运动速度和功率输出，负荷为单次重复最大值 (1RM) 的 25%、50%、75% 和 90%；(b) 85% 1RM 肌肉衰竭的卧推练习中重复次数的质量和数量；(c) 反向跳跃测试中的垂直跳跃高度；(d) Wingate 测试中的功率输出。结果 与安慰剂相比，咖啡因摄入增强：(a) 所有负载的运动速度和功率输出（效应大小 [ES]：0.20–0.61；所有 p < 0.05）；(b) 85% 的 1RM 重复的质量和数量（ES：0.27–0.85；所有 p < 0.001）；(c) 垂直跳跃高度 (ES: 0.15; p = 0.017); (d) Wingate 测试中的功率输出（ES：0.33–0.44；所有 p < 0.05）。在任何分析的性能结果中，我们都没有发现显着的基因型 × 咖啡因相互作用效应（p 值范围为 0.094 到 0.994）。结论 接受过抗阻训练的男性在摄入咖啡因后可能会在抗阻运动、跳跃和短跑方面的表现得到明显改善。比较咖啡因对 AA 基因型和 AC/CC 基因型个体之间运动表现的影响，没有发现显着差异。试验注册澳大利亚新西兰临床试验注册处。编号：ACTRN12619000885190。