Objective

Migraine is a complex episodic disease manifested by dysfunction of the sympathetic nervous system along with numerous neuropsychiatric symptoms. The aim of this study was to identify the dissociative symptoms with neurobiological similarities in episodic and chronic migraine patients and to evaluate their correlation with migraine frequency and severity of attacks.

Methods

The study included 61 episodic, 45 chronic migraine patients diagnosed using the criteria of the International Headache Society and 54 healthy control subjects. Dissociative Experiences Scale, Beck Anxiety Scale and Beck Depression Inventory were filled with the interviews. Demographic, clinical and headache characteristics of the patients were recorded according to migraine types. Results were analyzed by Kruskal–Wallis method and Spearman’s correlation tests.

Results

Dissociative symptoms were more common in the patients with chronic migraine, and there was a statistically significant difference between the chronic migraine group and the episodic migraine and control groups (p = 0.001, p < 0.001). Dissociative experiences were correlated with depression and anxiety findings, and in both groups, there was a significant correlation between clinical characteristics of migraine and osmophobia in the controlled partial correlation analysis (p < 0.05).

Conclusion

This study revealed that dissociative symptoms are more common especially in patients with chronic migraine and there is a significant association with osmophobia in both migraine groups. According to these data, we think that dissociative symptoms in chronic migraine patients will be questioned and osmophobia may be a guide in this regard.

中文翻译：

---

偏头痛中分离经历的影响及其与恐惧症的密切关系。

目的

偏头痛是一种复杂的发作性疾病，表现为交感神经系统功能障碍以及许多神经精神症状。这项研究的目的是确定发作性和慢性偏头痛患者具有神经生物学相似性的分离症状，并评估其与偏头痛发作频率和严重程度的相关性。

方法

该研究包括61名发作性，45名根据国际头痛协会标准诊断出的慢性偏头痛患者和54名健康对照者。访谈中包括了离解性经验量表，贝克焦虑量表和贝克抑郁量表。根据偏头痛类型记录患者的人口统计学，临床和头痛特征。结果通过Kruskal–Wallis方法和Spearman相关检验进行分析。

结果

分离性症状在慢性偏头痛患者中更常见，并且慢性偏头痛组与发作性偏头痛和对照组之间存在统计学上的显着差异（p = 0.001，p <0.001）。解离的经历与抑郁和焦虑的发现相关，并且在两组之间，偏头痛和恐惧症的临床特征之间的显着相关性在对照的部分相关性分析中（p <0.05）。

结论

这项研究表明，分离性症状更常见，尤其是在慢性偏头痛患者中，并且在两个偏头痛组中，恐惧症都有显着的关联。根据这些数据，我们认为慢性偏头痛患者的分离症状会受到质疑，而恐同可能是这方面的指南。