Electrospinning polyurethane has been utilized as skin wound dressing for protecting skin wounds from infection and thus facilitating their healings, but also limited by its imperfect biocompatibility, mechanical and antibacterial properties. This paper presents our study on the addition of graphene oxide to electrospinning polyurethane for improved properties, as well as its in vitro characterization. Polyurethane/graphene oxide wound dressing was electrospun with varying amount of graphene oxide (from 0.0% to 2.0%); and in vitro tests was carried out to characterize the wound dressing properties and performance from the structural, mechanical, and biological perspectives. Scanning electron microscopy and Fourier-transform infrared spectroscopy were used to confirm the interaction between graphene oxide particles and polyurethane fibers, while the scanning electron microscopy images further illustrated that the wound dressing was of a porous structure with fibre diameters depending on the amount of graphene oxide added; specifically, 20 to 180 nm were for composite polyurethane/graphene oxide fibers and 600 to 900 nm for pure polyurethane. Our results also revealed that the hydrophilicity and swelling properties of the wound dressing could be regulated by the amount of graphene oxide added to the polyurethane/graphene oxide composites. Mechanical, antibacterial, and cytotoxicity properties of the composite polyurethane/graphene oxide wound dressing were examined with the results illustrating that the addition of graphene oxide could improve the properties of the electrospun wound dressing. Combined together, our study illustrates that electrospinning polyurethane/graphene oxide composite is promising as skin wound dressing.

静电纺丝聚氨酯已被用作皮肤伤口敷料，以保护皮肤伤口免受感染，从而促进其愈合，但也受到其不完善的生物相容性、机械和抗菌性能的限制。本文介绍了我们在静电纺丝聚氨酯中添加氧化石墨烯以改善性能的研究，以及其体外表征。聚氨酯/氧化石墨烯伤口敷料是用不同量的氧化石墨烯（从 0.0% 到 2.0%）静电纺丝的；并进行了体外测试，以从结构、机械和生物学角度表征伤口敷料的特性和性能。使用扫描电子显微镜和傅里叶变换红外光谱来确认氧化石墨烯颗粒与聚氨酯纤维之间的相互作用，而扫描电镜图像进一步说明伤口敷料是多孔结构，纤维直径取决于氧化石墨烯的添加量；具体而言，20 至 180 nm 用于复合聚氨酯/氧化石墨烯纤维，600 至 900 nm 用于纯聚氨酯。我们的结果还表明，伤口敷料的亲水性和溶胀性能可以通过添加到聚氨酯/氧化石墨烯复合材料中的氧化石墨烯的量来调节。研究了复合聚氨酯/氧化石墨烯伤口敷料的机械、抗菌和细胞毒性，结果表明添加氧化石墨烯可以改善电纺伤口敷料的性能。结合在一起，