Aims: A series of six 4-benzylidene-2-((1-phenyl-3,4-dihydro isoquinoline-2(1H)-yl)methyloxazol- 5(4H)-one derivatives were synthesized by condensation of substituted aryl aldehydes with 2-(2-(1-phenyl-3,4- dihydro isoquinoline-2(1H)-acetamido)acetic acid in the presence of sodium acetate, acetic anhydride and zinc oxide as catalysts.

Background: Novel Synthesis of 4-Benzylidene-2-((1-phenyl-3,4-dihy droisoquinoline-2(1H)-yl)methyl)oxazol- 5(4H)-one derivatives using 1,2,3,Tetrahydroisoquinoline and their antimicrobial activity.

Objective: The title compounds can be synthesized from 1,2,3,4-tetrahydroisoquinoline.

Methods: The target molecules, i.e., 4-benzylidene-2-((1-phenyl-3, 4-dihydro isoquinoline-2(1H)-yl) methyl) oxazol-5(4H)-one derivatives (8a-8f) have been synthesized from 1,2,3,4-tetrahydroisoquinoline which was prepared from benzoic acid in few steps.

Results: All the six compounds were evaluated based on advanced spectral data (1H NMR, 13C NMR & LCMS), and the chemical structures of all compounds were determined by elemental analysis.

Conclusion: Antibacterial activity of the derivatives was examined for the synthesized compounds and results indicate that compound with bromine substitution has a good activity profile.

目的：通过取代的芳基醛缩合，合成了一系列的六个4-亚苄基-2-（（（1-苯基-3,4-二氢异喹啉-2（1H）-基）甲基恶唑-5（4H）-一）衍生物在乙酸钠，乙酸酐和氧化锌作为催化剂存在下的2-（2-（1-苯基-3,4-二氢异喹啉-2（1H）-乙酰氨基）乙酸。

背景：使用1,2,3，四氢异喹啉新颖合成4-苄叉基-2-（（1-苯基-3,4-二氢droisoquinoline-2（1H）-基）甲基）恶唑-5（4H）-一衍生物及其抗菌活性。

目的：可由1,2,3,4-四氢异喹啉合成标题化合物。

方法：目标分子，即4-亚苄基-2-（（（1-苯基-3，4-二氢异喹啉-2（1H）-基）甲基）恶唑-5（4H）-一衍生物（8a-8f）已经由1,2,3,4-四氢异喹啉合成，它是由苯甲酸在几个步骤中制备的。

结果：根据先进的光谱数据（1H NMR，13C NMR和LCMS）对所有6种化合物进行了评估，并通过元素分析确定了所有化合物的化学结构。

结论：检测了该衍生物对合成化合物的抗菌活性，结果表明具有溴取代基的化合物具有良好的活性。