Well-designed and properly conducted randomized clinical trials provide a true estimate of the effects of interventions and are acknowledged as the gold standard in terms of clinical study design. However, the quality of randomized clinical trials published in the field of Endodontics is suboptimal. The Preferred Reporting Items for RAndomized Trials in Endodontics (PRIRATE) 2020 guidelines were developed exclusively for Endodontics by integrating and adapting the CONsolidated Standards of Reporting Trials (CONSORT) statement and Clinical and Laboratory Images in Publications (CLIP) principles, through an accepted and well-documented consensus process. Full implementation of the PRIRATE 2020 guidelines will minimize potential sources of bias and thus enhance the standard of manuscripts submitted for publication, which will ultimately improve the reporting of randomized clinical trials in Endodontics. The aim of this document is to provide an explanation for each item in the PRIRATE 2020 checklist and flowchart with examples from the literature in order to help authors understand their rationale and significance. A link to this PRIRATE 2020 explanation and elaboration document is available on the Preferred Reporting Items for study Designs in Endodontology (PRIDE) website at http://www.pride-endodonticguidelines.org/prirate/.

中文翻译：

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PRIRATE 2020 报告牙髓病随机试验指南：解释和阐述。

精心设计和正确实施的随机临床试验提供了对干预效果的真实估计，并被公认为临床研究设计的金标准。然而，在牙髓病学领域发表的随机临床试验的质量并不理想。2020 年牙髓病随机试验的首选报告项目 (PRIRATE) 指南是专门为牙髓病学制定的，通过整合和调整报告试验的综合标准 (CONSORT) 声明和出版物中的临床和实验室图像 (CLIP) 原则，通过公认的良好- 记录的共识过程。PRIRATE 2020 指南的全面实施将最大限度地减少潜在的偏见来源，从而提高提交出版手稿的标准，这将最终改善牙髓病随机临床试验的报告。本文档旨在通过文献中的示例为 PRIRATE 2020 清单和流程图中的每个项目提供解释，以帮助作者了解其基本原理和意义。此 PRIRATE 2020 解释和详细说明文件的链接可在牙髓病学研究设计的首选报告项目 (PRIDE) 网站上获得，网址为 http://www.pride-endodonticguidelines.org/prirate/。