Introduction: Nasal mucus is the first line defense barrier against various pathogens including allergens. Proteins in nasal mucus maybe used as biomarkers for diagnosis or future therapeutic strategies. Proteomics opens the possibility to investigate whole human proteomes.Areas Covered: We aimed to analyze the existing literature on nasal mucus and nasal secretions proteomic approaches especially in allergic rhinitis. A PubMed/Medline search was conducted entering the following keywords and combinations: "nasal mucus", "nasal lavage fluid," nasal secretions," "nasal swabs," "allergic rhinitis," "proteins," and "proteomics."Expert opinion: The majority of studies focus on single proteins or protein groups mainly using ELISA techniques. Four studies met the criteria using mass spectrometry in the analysis of nasal mucus proteomes in rhinologic diseases. In these studies, 7, 35, 267, and 430 proteins were identified, respectively. These four studies are discussed in this review and put in relation to seven other proteomic studies that focus on nasal lavage fluid and nasal secretions obtained by swabs or filter paper. To put it in a nutshell, proteomics facilitates the investigation of the nasal secretome and its role in healthy and diseased state and as potential biomarkers for new diagnostic or therapeutic approaches.

中文翻译：

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鼻粘液蛋白质组及其在过敏性鼻炎中的参与。

简介：鼻黏液是抵御包括过敏原在内的各种病原体的第一道防线。鼻粘液中的蛋白质可用作诊断或未来治疗策略的生物标志物。蛋白质组学为研究整个人类蛋白质组开辟了可能性。涵盖的领域：我们旨在分析有关鼻粘液和鼻分泌物蛋白质组学方法的现有文献，尤其是在过敏性鼻炎中。输入以下关键字和组合进行 PubMed/Medline 搜索：“鼻粘液”、“鼻腔灌洗液”、“鼻腔分泌物”、“鼻拭子”、“过敏性鼻炎”、“蛋白质”和“蛋白质组学”。专家意见：大多数研究集中在单一蛋白质或蛋白质组上，主要使用 ELISA 技术。四项研究符合使用质谱法分析鼻科疾病鼻黏液蛋白质组的标准。在这些研究中，分别鉴定了 7、35、267 和 430 种蛋白质。本综述讨论了这四项研究，并将其与其他七项蛋白质组学研究相关联，这些研究侧重于通过拭子或滤纸获得的鼻腔灌洗液和鼻腔分泌物。简而言之，蛋白质组学有助于研究鼻分泌物组及其在健康和疾病状态中的作用，并作为新诊断或治疗方法的潜在生物标志物。本综述讨论了这四项研究，并将其与其他七项蛋白质组学研究相关联，这些研究侧重于通过拭子或滤纸获得的鼻腔灌洗液和鼻腔分泌物。简而言之，蛋白质组学有助于研究鼻分泌物组及其在健康和疾病状态中的作用，并作为新诊断或治疗方法的潜在生物标志物。本综述讨论了这四项研究，并将其与其他七项蛋白质组学研究相关联，这些研究侧重于通过拭子或滤纸获得的鼻腔灌洗液和鼻腔分泌物。简而言之，蛋白质组学有助于研究鼻分泌物组及其在健康和疾病状态中的作用，并作为新诊断或治疗方法的潜在生物标志物。