Cervical cancer is one of the most common cancers in the world while its pathological mechanisms are not well-elucidated. Long non-coding RNA (lncRNA) has been implicated in cancer development. The dysregulation of lncRNA myocardial infarction-associated transcript (MIAT) has been reported in several cancers while its role in cervical cancer is not described yet. In this study, the role of MIAT in cervical cancer was explored. We evaluated the expression of MIAT in cervical cancer tissues and cell lines. Furthermore, we explored the effects of MIAT on proliferation and invasion of cervical cancer using cell model and animal transplantation model. We also evaluated the effects of MIAT on activation of PI3K/Akt/mTOR signalling pathway. Our results show that MIAT was up-regulated in cervical cancer tissues and cell lines. Knocking down MIAT resulted in decreased cell proliferation, migration and invasion of cervical cancer cells and suppression of tumour growth in mice. Mechanically, knocking down MIAT suppressed the activation of PI3K/Akt signalling pathway. In conclusion, MIAT promotes cell proliferation and invasion in cervical cancer.

中文翻译：

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长的非编码RNA MIAT促进宫颈癌的增殖和迁移。

宫颈癌是世界上最常见的癌症之一，但其病理机制尚不清楚。长的非编码RNA（lncRNA）已牵涉到癌症的发展。已经在几种癌症中报告了lncRNA心肌梗死相关转录本（MIAT）的失调，但尚未描述其在宫颈癌中的作用。在这项研究中，探讨了MIAT在子宫颈癌中的作用。我们评估了MIAT在宫颈癌组织和细胞系中的表达。此外，我们使用细胞模型和动物移植模型探索了MIAT对子宫颈癌增殖和侵袭的影响。我们还评估了MIAT对PI3K / Akt / mTOR信号通路激活的影响。我们的结果表明，MIAT在宫颈癌组织和细胞系中上调。降低MIAT会导致细胞增殖减少，子宫颈癌细胞的迁移和侵袭以及小鼠肿瘤生长的抑制。机械上，敲低MIAT可抑制PI3K / Akt信号通路的激活。总之，MIAT促进宫颈癌中的细胞增殖和侵袭。