Introduction: The development of more effective vaccines for the control of tick infestations and pathogen transmission is essential for prevention and control of tick-borne diseases worldwide. Recently, the application of omics technologies has advanced the identification of tick protective antigens. However, other factors such as vaccine formulation and implementation need to be addressed, and tick vaccine modeling will contribute to improve the efficacy of vaccination strategies.Areas covered: In this review, we summarized current information on tick vaccine correlates of protection and modeling, and proposed new approaches to improve vaccine evaluation and implementation using as a proof-of-concept the Hyalomma marginatum-Crimean-Congo hemorrhagic fever virus model due to its high mortality rate and potentially growing impact on human health.Expert opinion: Vaccines are required as an effective and environmentally sound intervention for the control of tick-borne diseases affecting human and animal health worldwide. Despite recent advances in the identification of candidate tick protective antigens, research on vaccine formulation and implementation need to be addressed to improve tick vaccine control efficacy. As shown here, modeling of the vaccination strategies against ticks and transmitted pathogens will contribute to vaccine development by guiding the selection of appropriate antigen combinations, target hosts, and vaccination time schedule.

中文翻译：

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tick疫苗建模：提高保护效力的关键工具。

简介：开发控制effective虫感染和病原体传播的更有效疫苗对于预防和控制全世界control传播疾病至关重要。最近，组学技术的应用促进了of虫保护性抗原的鉴定。但是，还需要解决疫苗配制和实施等其他因素，壁虱疫苗建模将有助于提高疫苗接种策略的效力。涵盖的领域：在本综述中，我们总结了关于壁虱疫苗的保护和建模相关信息，以及由于其高死亡率和对人体健康的潜在影响，因此提出了一种新的方法来改进疫苗的评估和实施，并以概念证明来使用边缘透明质酸-克里米亚-刚果出血热病毒模型。专家意见：需要疫苗作为一种有效且对环境无害的干预措施，以控制影响全世界人类和动物健康的tick传播疾病。尽管在候选壁虱保护性抗原的鉴定方面取得了最新进展，但仍需要对疫苗的配制和实施进行研究以提高壁虱疫苗的控制功效。如此处所示，针对壁虱和传播​​的病原体的疫苗接种策略的建模将通过指导适当抗原组合，目标宿主和疫苗接种时间表的选择来促进疫苗开发。尽管在候选壁虱保护性抗原的鉴定方面取得了最新进展，但仍需要对疫苗的配制和实施进行研究以提高壁虱疫苗的控制功效。如此处所示，针对壁虱和传播​​的病原体的疫苗接种策略的建模将通过指导适当抗原组合，目标宿主和疫苗接种时间表的选择来促进疫苗开发。尽管在候选壁虱保护性抗原的鉴定方面取得了最新进展，但仍需要对疫苗的配制和实施进行研究以提高壁虱疫苗的控制功效。如此处所示，针对壁虱和传播​​的病原体的疫苗接种策略的建模将通过指导适当抗原组合，目标宿主和疫苗接种时间表的选择来促进疫苗开发。